White-nose syndrome without borders: Pseudogymnoascus destructans infection tolerated in Europe and Palearctic Asia but not in North America

Scientific Reports
Jan ZukalNatália Martínková

Abstract

A striking feature of white-nose syndrome, a fungal infection of hibernating bats, is the difference in infection outcome between North America and Europe. Here we show high WNS prevalence both in Europe and on the West Siberian Plain in Asia. Palearctic bat communities tolerate similar fungal loads of Pseudogymnoascus destructans infection as their Nearctic counterparts and histopathology indicates equal focal skin tissue invasiveness pathognomonic for WNS lesions. Fungal load positively correlates with disease intensity and it reaches highest values at intermediate latitudes. Prevalence and fungal load dynamics in Palearctic bats remained persistent and high between 2012 and 2014. Dominant haplotypes of five genes are widespread in North America, Europe and Asia, expanding the source region of white-nose syndrome to non-European hibernacula. Our data provides evidence for both endemicity and tolerance to this persistent virulent fungus in the Palearctic, suggesting that host-pathogen interaction equilibrium has been established.

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Citations

Apr 17, 2016·Microbial Ecology·Tomasz KokurewiczKrzysztof Matkowski
Sep 14, 2016·Scientific Reports·Miroslav FliegerJiri Pikula
Aug 10, 2016·MSphere·Jeffrey M LorchDavid S Blehert
Aug 3, 2017·PloS One·Jiri PikulaNatália Martínková
Apr 19, 2018·Scientific Reports·Hana BandouchovaJan Zukal
Apr 12, 2020·G3 : Genes - Genomes - Genetics·Thomas M LilleySteve Paterson
Oct 9, 2018·Frontiers in Immunology·Judith N MandlMichelle L Baker
Nov 29, 2017·Transboundary and Emerging Diseases·A ZahradníkováJ Pikula
Aug 19, 2017·Emerging Infectious Diseases·Michael G CampanaKristofer M Helgen
Jun 20, 2018·BMC Veterinary Research·Veronika KovacovaJiri Pikula
Feb 10, 2017·Proceedings. Biological Sciences·T M LilleyK A Field
Jul 8, 2020·BMC Veterinary Research·Jiri PikulaJan Zukal
Sep 5, 2020·Frontiers in Zoology·Natália MartínkováJan Zima
Dec 4, 2020·Veterinary Sciences·Valentina Virginia Ebani, Francesca Mancianti
Jan 20, 2021·Nature Reviews. Microbiology·Joseph R HoytKate E Langwig
Dec 12, 2020·BMC Veterinary Research·Veronika SeidlovaJiri Pikula
Jan 22, 2021·Developmental and Comparative Immunology·Marcus FritzeGábor Á Czirják
Feb 3, 2021·Transboundary and Emerging Diseases·Veronika SeidlovaJan Zukal
Jun 8, 2021·Current Opinion in Microbiology·Flora Whiting-FawcettThomas M Lilley

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Methods Mentioned

BETA
biopsy
biopsies
PCR

Software Mentioned

cellSense
R
Geneious
ImageJ

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