PMID: 11912049Mar 26, 2002Paper

White-sided dolphin metallothioneins: purification, characterisation and potential role

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
K DasJean-Marie Bouquegneau

Abstract

Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver and kidney. The protein has two isoforms: MT-1 and MT-2. MT-1 binds Cu, Zn, Hg and Cd, while MT-2 only binds Zn, Hg and Cd. This suggests different metabolic functions for the two isoforms: MT-1 is mainly involved in Cu homeostasis; MT-2, which was four-fold more abundant than MT-1, detoxifies most of the accumulated cadmium.

References

Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Wagemann, B Hobden
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Nov 27, 1999·Nephron·G HellemansM De Ley

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Citations

Mar 1, 2012·Analytical and Bioanalytical Chemistry·T García-BarreraV Gómez-Jacinto
Oct 12, 2011·Environmental Science & Technology·Andrea H BuckmanPeter S Ross
Jan 18, 2011·Journal of Endodontics·Chia-Yung LinMin-Huey Chen
Aug 23, 2020·Chemosphere·Marina RenedoPaco Bustamante

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