White sponge naevus with minimal clinical and histological changes: report of three cases

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Alberta Lucchese, Gianfranco Favia

Abstract

White sponge naevus (WSN) is a rare autosomal dominant disorder that predominantly affects non-cornified stratified squamous epithelia: oral mucosa, oesophagus, anogenital area. It has been shown to be related to keratin defects, because of mutations in the genes encoding mucosal-specific keratins K4 and K13. We illustrate three cases diagnosed as WSN, following the clinical and histological criteria, with unusual appearance. They presented with minimal clinical and histological changes that could be misleading in the diagnosis. The patients showed diffuse irregular plaques with a range of presentations from white to rose coloured mucosae involving the entire oral cavity. In one case the lesion was also present in the vaginal area. The histological findings included epithelial thickening, parakeratosis and extensive vacuolization of the suprabasal keratinocytes, confirming WSN diagnosis. Clinical presentation and histopathology of WSN are discussed in relation to the differential diagnosis of other oral leukokeratoses.

References

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Citations

Feb 29, 2008·Pediatric Dermatology·Pía López Jornet
Jan 11, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michele D MignognaCarlo Cafiero
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May 9, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jianming ZhangXu Zhang
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Oct 1, 2019·Journal of Cutaneous Pathology·Kelly T BezerraMário J Romañach
Sep 19, 2019·The Canadian Journal of Nursing Research = Revue Canadienne De Recherche En Sciences Infirmières·Jenna Menard-Kocik, Vera Caine
Sep 8, 2017·Clinical Case Reports·Stephanie B de HasethFrederik J Hes
Sep 27, 2020·Transboundary and Emerging Diseases·Miri HyunHyun Ah Kim

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