Whither systems medicine?

Experimental & Molecular Medicine
Rolf ApweilerOlaf Wolkenhauer

Abstract

New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.

References

Nov 15, 2002·Nature·Hiroaki Kitano
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·John McCarthy
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·Kevin A Janes, Michael B Yaffe
Nov 8, 2008·The International Journal of Behavioral Nutrition and Physical Activity·Stéphanie A PrinceMark Tremblay
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gary AnYoram Vodovotz
Mar 3, 2011·Nature Reviews. Clinical Oncology·Leroy Hood, Stephen H Friend
Nov 4, 2011·Nature Reviews. Genetics·Samik GhoshHiroaki Kitano
Jan 13, 2012·Annual Review of Pharmacology and Toxicology·Shan Zhao, Ravi Iyengar
Jan 15, 2013·Pediatric Research·Olaf WolkenhauerOlaf Dammann
Mar 28, 2013·Current Pharmaceutical Design·Annabelle Ballesta, Jean Clairambault
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Michael J GerdesFiona Ginty
Jul 18, 2014·Genome Medicine·Olaf WolkenhauerHelen Byrne
Jul 18, 2014·BMC Systems Biology·David Gomez-CabreroJesper Tegnér
Oct 10, 2015·Trends in Genetics : TIG·Assieh SaadatpourGuo-Cheng Yuan
Dec 17, 2015·Nature Reviews. Drug Discovery·James R HeathPaul S Mischel
Jan 20, 2016·CPT: Pharmacometrics & Systems Pharmacology·J CosgroveM Coles
May 14, 2016·Nature Reviews. Drug Discovery·Antigoni ElefsiniotiJoachim Reischl
Jul 31, 2016·Molecular Systems Biology·Christof AngermuellerOliver Stegle
Sep 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manuela SalvucciJochen H M Prehn
Sep 30, 2016·The New England Journal of Medicine·Ziad Obermeyer, Ezekiel J Emanuel
Nov 5, 2016·Annual Review of Pharmacology and Toxicology·Lei XiePhilip E Bourne
Jan 21, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Tamas KorcsmarosGiulio Superti-Furga

❮ Previous
Next ❯

Citations

Jun 15, 2020·Clinical Pharmacology and Therapeutics·Nicholas J SchorkJeffrey Trent
Aug 23, 2020·Journal of Integrative Bioinformatics·Søren BrunakDagmar Waltemath
Oct 23, 2018·Frontiers in Oncology·Francesca Finotello, Federica Eduati
May 11, 2018·Acta Biotheoretica·Angélique StéphanouAnnabelle Ballesta
Jan 30, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Jennifer A SchaubMatthias Kretzler
Nov 14, 2019·BMC Cancer·Manuela SalvucciJochen H M Prehn
Nov 17, 2020·Briefings in Bioinformatics·Haiying WangHuiru Zheng
Feb 2, 2021·Frontiers in Microbiology·Alessandra RomanoFrancesco Gonella
Jan 13, 2021·International Journal of Molecular Sciences·Julio VeraMartin Eberhardt
Feb 16, 2021·Computational and Systems Oncology·Heiko Enderling, Olaf Wolkenhauer

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
imaging techniques
single-cell sequencing
chips

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioMed Research International
Zhongming ZhaoWanwipa Vongsangnak
Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
D B DavisonM S Waterman
Yearbook of Medical Informatics
K C Lun
© 2022 Meta ULC. All rights reserved