PMID: 6105515Aug 23, 1980Paper

W.H.O. cooperative trial on primary prevention of ischaemic heart disease using clofibrate to lower serum cholesterol: mortality follow-up. Report of the Committee of Principal Investigators

Lancet

Abstract

This is a further report on the mortality amongst men in the W.H.O. cooperative trial of the primary prevention of ischaemic heart disease (IHD) by clofibrate. Mean observation was 9.6 years, 5.3 in the trial and 4.3 afterwards; 911 deaths are recorded in 150 000 man-years. There were 25% more deaths in the clofibrate-treated group than in the comparable, high serum cholesterol, control group (p < 0.01), and there was an excess in the treated group in all the three participating centres. Mortality from all causes was higher in the treated group than in the high cholesterol controls during the trial, equal in the first two years after leaving the trial, but higher again after that. No particular disease accounted for the overall excess: the treated group had more deaths from IHD, stroke, cancer, and other major diseases though most of these differences were not individually significant. There was no excess in deaths due to accidents and violence. There was also a significant excess in the death rate from all causes, and from causes other than IHD, in the treated group compared with the second, low cholesterol, control group. No relationship could be shown between the excess mortality and cholesterol reduction, or the length of t...Continue Reading

References

May 10, 1975·Lancet·J CooperM F Oliver
Mar 8, 1980·Lancet·G Rose, M J Shipley

❮ Previous
Next ❯

Citations

Sep 1, 1992·Clinical Cardiology·W S Harris
Jan 1, 1997·Cardiovascular Drugs and Therapy·J R Hampton
Jun 25, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jeffrey M PetersFrank J Gonzalez
Apr 25, 2009·International Journal of Clinical Oncology·Qian Shi, Daniel J Sargent
Dec 21, 2000·Current Atherosclerosis Reports·M F Linton, S Fazio
Aug 7, 2004·Current Atherosclerosis Reports·Robert P Byington, Frank M Sacks
Mar 17, 2004·Current Atherosclerosis Reports·Sergio Fazio, MacRae F Linton
Jun 27, 1986·The American Journal of Cardiology·S B Hulley, M J Martin
Dec 5, 1992·Lancet·J A HeadyM F Oliver
Feb 20, 1993·Lancet·T A Sheldon, G D Smith
Jan 1, 1988·Pharmacology & Therapeutics·C R Sirtori, G Franceschini
Dec 1, 1983·Controlled Clinical Trials·W J Zukel
Dec 1, 1983·Controlled Clinical Trials·W F Krol
Dec 1, 1983·Controlled Clinical Trials·L FriedmanG L Knatterud
Jan 1, 1986·Social Science & Medicine·G GuyattR Labelle
May 17, 2005·Atherosclerosis·George Steiner
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrea Rita Horvath, Daniel Pewsner
Dec 6, 1980·Lancet·H KeenV Wynn
Jun 19, 1982·Lancet·M LambertJ P Butzler
Apr 9, 1983·Lancet·H C SimpsonL Woolf
Nov 10, 1984·Lancet·K G Green
May 19, 1984·Lancet·R MouliasB Lesourd
Aug 7, 2002·Pharmacology & Therapeutics·Helen VosperColin N A Palmer
May 1, 1985·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·E Belmaker, J D Cohen
Dec 1, 1986·Journal of the American College of Cardiology·P L CannerW Friedewald
Jun 13, 2003·Clinical Cornerstone·Alan J Garber
Aug 1, 1991·Journal of Internal Medicine·P M StuytA F Stalenhoef
May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·P H Winocour, M F Laker
Feb 8, 2008·Nutrition Reviews·Crystal M RasnakeTherese M Heinonen
May 12, 2006·The Heart Surgery Forum·Mutasim SungunAhmet Turan Yilmaz
Nov 1, 1995·Environmental Health Perspectives·P D Stolley, S H Zahm
Aug 14, 1998·BMJ : British Medical Journal·A Rosengren
Jul 11, 2006·The Journal of Clinical Investigation·Clay F Semenkovich
Nov 14, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Eddie Vos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.