Who gave whom hemoglobin S: The use of restriction site haplotype variation for the interpretation of the evolution of the β(S) -globin gene

American Journal of Human Biology : the Official Journal of the Human Biology Council
Frank B Livingstone

Abstract

The hypothesis that three separate mutations to the β(S) -globin gene have occurred in Africa in challenged. The distributions of the β(S) and other β-globin haplotypes and a simulation of the diffusion of the β(S) gene are presented and argued to be more in accord with the rapid diffusion of a single mutant that by recombination and gene conversion now occurs on several different haplotypes.

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