Whole Blood for Resuscitation in Adult Civilian Trauma in 2017: A Narrative Review

Anesthesia and Analgesia
Evan G PivalizzaB A Cotton

Abstract

After a hiatus of several decades, the concept of cold whole blood (WB) is being reintroduced into acute clinical trauma care in the United States. Initial implementation experience and data grew from military medical applications, followed by more recent development and data acquisition in civilian institutions. Anesthesiologists, especially those who work in acute trauma facilities, are likely to be presented with patients either receiving WB from the emergency department or may have WB as a therapeutic option in massive transfusion situations. In this focused review, we briefly discuss the historical concept of WB and describe the characteristics of WB, including storage, blood group compatibility, and theoretical hemolytic risks. We summarize relevant recent retrospective military and preliminary civilian efficacy as well as safety data related to WB transfusion, and describe our experience with the initial implementation of WB transfusion at our level 1 trauma hospital. Suggestions and collective published experience from other centers as well as ours may be useful to those investigating such a program. The role of WB as a significant therapeutic option in civilian trauma awaits further prospective validation.

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Citations

Sep 21, 2018·Anesthesia and Analgesia·Evan G PivalizzaBryan A Cotton
Sep 21, 2018·Anesthesia and Analgesia·Sergio B NavarreteMichael J Scott
Jan 30, 2019·Current Opinion in Anaesthesiology·Corey Scher, Robert Mansky
Oct 2, 2019·Current Opinion in Critical Care·Ruben PeraltaSandro Rizoli
Apr 14, 2019·Transfusion·Pampee P Young, P Dayand Borge
Aug 30, 2019·The Journal of Trauma and Acute Care Surgery·James WilliamsBryan A Cotton
Mar 12, 2020·World Journal of Surgery·Alhassan Datti MohammedAna Maria Crawford
Sep 16, 2020·Internal and Emergency Medicine·Mario CrucianiGiancarlo Maria Liumbruno
Mar 1, 2019·Current Opinion in Anaesthesiology·Robert Mansky, Corey Scher
Oct 23, 2020·Transfusion·Andrew C SayceChristine M Leeper
Mar 17, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·P Keerthi VasanRishi Mugesh Kanna
Jan 7, 2021·The Journal of Trauma and Acute Care Surgery·Thomas ClementsBryan A Cotton
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Oct 31, 2020·Shock·Christopher Cameron McCoyBryan A Cotton

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