Whole Blood Gene Expression Associated With Clinical Biological Age

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Honghuang LinJoanne M Murabito

Abstract

Biologic age may better reflect an individual's rate of aging than chronologic age. We conducted a transcriptome-wide association study with biologic age estimated with clinical biomarkers, which included: systolic blood pressure, forced expiratory volume at 1 second (FEV1), total cholesterol, fasting glucose, C-reactive protein, and serum creatinine. We assessed the association between the difference between biologic age and chronologic age (∆age) and gene expression in whole blood measured using the Affymetrix Human Exon 1.0st Array. Our discovery sample included 2,163 participants from the Framingham Offspring cohort (mean age 67 ± 9 years, 55% women). A total of 481 genes were significantly associated with ∆age (p < 2.8 × 10-6). Among them, 415 genes were validated (p < .05/481 = 1.0 × 10-4) in 2,946 participants from the Framingham Third Generation cohort (mean age 46 ± 9 years, 53% women). Many of the significant genes were involved in the ubiquitin-mediated proteolysis pathway. The replication in 414 Rotterdam Study participants (mean age 59 ± 8, 52% women) found 104 of 415 validated genes reached nominal significance (p < .05). We identified and validated 415 genes associated with ∆age in a community-based cohort. Futur...Continue Reading

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Citations

Jun 11, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xin ZhongTze Pin Ng
Oct 24, 2018·International Journal of Molecular Sciences·Francesco VillaAnnibale Alessandro Puca
Nov 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John C EarlsNathan D Price
Jul 2, 2020·Ecology and Evolution·Atsushi IkemotoMasakado Kawata
Sep 11, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lauren C TindaleAngela R Brooks-Wilson
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Feb 5, 2021·Scientific Reports·Maximilian KönigIlja Demuth
Jul 20, 2021·IScience·Panagiotis NtostisDavid Miller

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