Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study.

PloS One
Joel SalinasSudha Seshadri

Abstract

Emerging evidence suggests microRNAs (miRNAs) may play an important role in explaining variation in stroke risk and recovery in humans, yet there are still few longitudinal studies examining the association between whole blood miRNAs and stroke. Accounting for multiple testing and adjusting for potentially confounding technical and clinical variables, here we show that whole blood miR-574-3p expression was significantly lower in participants with chronic stroke compared to non-cases. To explore the functional relevance of our findings, we analyzed miRNA-mRNA whole blood co-expression, pathway enrichment, and brain tissue gene expression. Results suggest miR-574-3p is involved in neurometabolic and chronic neuronal injury response pathways, including brain gene expression of DBNDD2 and ELOVL1. These results suggest miR-574-3p plays a role in regulating chronic brain and systemic cellular response to stroke and thus may implicate miR-574-3p as a partial mediator of long-term stroke outcomes.

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Citations

Sep 18, 2020·International Journal of Molecular Sciences·Kirill V BulyginGjumrakch Aliev
Aug 29, 2020·Journal of Personalized Medicine·Laura Le GallStephanie Duguez
Oct 9, 2019·British Journal of Biomedical Science·P Waller, A D Blann
Nov 10, 2020·Frontiers in Immunology·Chanan MeydanHermona Soreq
Feb 11, 2021·Stroke; a Journal of Cerebral Circulation·Michelle M J MensMohsen Ghanbari
Mar 8, 2021·Genomics·Vishal Chavda, Kajal Madhwani

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Methods Mentioned

BETA
RNA collection
blood collection

Software Mentioned

WebGestalt

Related Concepts

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A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.