Whole Blood Platelet Aggregation Test and Prediction of Hemostatic Difficulty After Tooth Extraction in Patients Receiving Antiplatelet Therapy

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Yasushi NagaoTakehiko Iijima

Abstract

When patients on antiplatelet therapy (APT) require minor invasive surgery, APT is usually continued to limit the risk of thrombosis. However, the possibility of hemostatic difficulties necessitates the monitoring of platelet aggregation to prevent unexpected bleeding. We examined whether whole blood aggregometry as a point-of-care testing (POCT) could be useful as a tool for predicting hemostatic difficulties. Sixty-five patients receiving APT and 15 patients who were not receiving APT were enrolled in the present study; all patients were scheduled to undergo a tooth extraction. Whole blood samples were obtained and were examined using multiple electrode aggregometry. The aggregometry was performed using arachidonic acid (AA), adenosine diphosphate (ADP), and thrombin receptor activating peptide. Hemostatic difficulty was defined as a need for more than 10 minutes of compression to achieve hemostasis. The AA test results were significantly lower in patients treated with aspirin (control: 97.7 [29.0] U, aspirin: 14.5 [7.2] U, P < .001). The ADP test results were also significantly lower in patients treated with a P2Y12 inhibitor (control: 77.7 [21.7] U, P2Y12 inhibitor: 37.3 [20.4] U, P < .01). Six of the examined cases exhibit...Continue Reading

References

Dec 1, 2009·Journal of Thrombosis and Haemostasis : JTH·D SibbingA Kastrati
Feb 17, 2010·Journal of Thrombosis and Thrombolysis·Gianluca CampoRoberto Ferrari
Jun 22, 2010·European Journal of Medical Research·A A HankeK Görlinger
Dec 22, 2010·The Annals of Thoracic Surgery·Marco RanucciUNKNOWN Surgical and Clinical Outcome Research (SCORE) Group
Jun 2, 2011·Platelets·Gianluca CampoRoberto Ferrari
Jul 26, 2011·The American Journal of Cardiology·Theodoros LillisGeorge Giannoglou
Jan 22, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Joel J NapeñasDenise E van Diermen
Jul 25, 2014·International Journal of Laboratory Hematology·R KongM Arcari
Aug 30, 2014·Journal of the American College of Cardiology·Katharina MayerDirk Sibbing
Sep 12, 2014·British Journal of Anaesthesia·M RanucciUNKNOWN Surgical and Clinical Outcome Research (SCORE) Group
Oct 15, 2014·The British Journal of Oral & Maxillofacial Surgery·Branislav V BajkinIvana A Bajkin
Nov 30, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Olga Olmos-CarrascoInmaculada Peña-Sainz
Dec 3, 2014·Journal of International Society of Preventive & Community Dentistry·Dattatraya A DarawadeAnuj Vasantray Mansata
Mar 4, 2015·Vascular Health and Risk Management·Rita PanicciaRosanna Abbate
May 20, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Seema AgarwalBilal Haneef Kirmani

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Citations

May 29, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zahra Ghafari
Jul 7, 2020·American Journal of Respiratory and Critical Care Medicine·Anna KontosDeclan Kennedy

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Methods Mentioned

BETA
coronary artery surgery
coronary artery bypass

Software Mentioned

pROC
SPSS
R

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