Whole blood viscosity assessment issues II: Prevalence in endothelial dysfunction and hypercoagulation.

North American Journal of Medical Sciences
Ezekiel Uba Nwose

Abstract

Virchow's triad in cardiovascular disease comprises blood viscosity, plasma D-dimer and homocysteine as indices of three associated but separate vascular phenomena. This work investigates prevalence of hyperviscosity in hyperhomocysteinaemia and positive D-dimer; and differences or similarities in stasis status among sub-populations of hyperhomocysteinaemia vs. normohomocysteinaemia and negative vs. positive D-dimer. 10-years de-identified archived clinical pathology data for the period of January 1999 to December 2008 were audited. All cases tested for D-dimer (n=6845) and homocysteine (n=1665), which were concomitantly tested for haematocrit and total proteins, were extracted. The results show a very low prevalence of hyperviscosity associated with a positive D-dimer sub-population (1.48%), which is not statistically different in comparison with the negative D-dimer sub-population. The prevalence of hyperviscosity associated with hyperhomocysteinaemia (5.04%) was statistically significantly higher in comparison to the normohomocysteinaemia sub-population (p = 0.05). The prevalence of low viscosity is significantly higher in the positive D-dimer sub-population relative to the negative D-dimer sub-population (p < 0.00001), but ...Continue Reading

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