Whole blood viscosity in microvascular angina and coronary artery disease: Significance and utility.

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Elif Ijlal Cekirdekci, Baris Bugan

Abstract

Whole blood viscosity (WBV) is the intrinsic resistance of blood flow in vessels, and when elevated induces endothelial shear stress and endothelial inflammation and can accelerate the atherosclerotic process. This study aims to compare WBV levels in patients with microvascular angina (MVA), patients with coronary artery disease (CAD), and normal controls, and to identify the relationship between WBV and high-sensitivity C-reactive protein as a marker of inflammation in MVA and CAD. A total of 573 patients were studied. The MVA group consisted of 189 subjects, the CAD group consisted of 203 subjects, and the control group consisted of 181 age- and gender-matched individuals. WBV was calculated from hematocrit and plasma protein concentration at a low shear rate (0.5 s-1) and high shear rate (208 s-1) by a validated equation. Patients with CAD and MVA had significantly higher WBV at both low and high shear rates compared to the control group. Correlation analysis revealed a significant relationship between high-sensitivity C-reactive protein and WBV at low (r=0.556; p<0.001) and high shear rates (r=0.562) in the CAD group and at low (r=0.475) and high shear rates (r=0.493) in the MVA group. Overall, this study demonstrated a sig...Continue Reading

Citations

Oct 16, 2020·Biomarkers in Medicine·Abdullah K DoluUmit Guray
Jun 29, 2021·Frontiers in Bioengineering and Biotechnology·Andrew IskanderNiema Pahlevan
Sep 4, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ahmet Akdi, Kadriye Gayretli Yayla

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