Whole blood viscosity issues VI: Association with blood salicylate level and gastrointestinal bleeding.

North American Journal of Medical Sciences
Ezekiel Uba Nwose, Nathan Cann

Abstract

This series on whole blood viscosity issues has been trying to elucidate the sensitivity, specificity and usefulness of the laboratory parameter in clinical practice. The postulation has been that since antiplatelet is used in the management of stasis, of which blood viscosity is an index, the latter would be useful laboratory indication and/or contraindication. The aim of this study was to observe whether blood level of acetylsalicylic acid differs with the level of whole blood viscosity. Out of the ten years database, 538 cases that were concomitantly tested for haematocrit, total proteins and blood level of salicylate were selected for this study. A separate nine cases of positive faecal occult blood tests were audited for blood viscosity and reviewed. A statistically significant difference is observed with lower blood viscosity being associated with higher salicylate level in comparison of the former between the highest vs. lowest quartiles (p < 0.002). This observation demonstrates the effect of aspirin in lowering blood stasis. Reviewing the positive faecal occult blood cases indicate that gastrointestinal bleeding is characterized by relative hypoviscosity and that hyperviscosity is not present during bleeding complicati...Continue Reading

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Citations

Apr 28, 2012·North American Journal of Medical Sciences·Ezekiel Uba Nwose, Ross Stuart Richards
Aug 1, 2014·North American Journal of Medical Sciences·Ezekiel U NwosePhillip T Bwititi
Mar 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Bei LiShankai Yin
Jun 14, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Neel K RanganathNader Moazami

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