Whole blood viscosity issues VII: The correlation with leucocytosis and implication on leukapheresis.

North American Journal of Medical Sciences
Ezekiel Uba Nwose, Ross Stuart Richards

Abstract

Blood hyperviscosity has been acknowledged to be a complicating factor in polycythaemia and hyperproteinaemia. Hyperleucocytosis has also been implicated in hyperviscosity and may be a basis for therapeutic leukapheresis. This issue in the series seeks to determine the association and correlation between whole blood viscosity and white blood cell count (WBCC), with a view to advance the cause of a neglected clinical pathology index. MATERIALS #ENTITYSTARTX00026; Based on archived clinical pathology data, 10,857 cases that were concomitantly tested for full blood count and total proteins in the 2008 calendar year were audited for hyperleucocytosis. Whole blood viscosity level was determined and compared in the group with leucocytosis relative to the group with leucopenia and normal WBCC. The confounding effects of age, gender and red blood cell indices were evaluated. The correlation between whole blood viscosity and WBCC was also determined. As a generalization, hypoviscosity is observed among individuals who presented hyperleucocytosis. There is no correlation (r = 0.20) between leucocytosis and blood viscosity. It is known that anaemia and thromboembolism, which can be associated with leucocytosis, predispose to hypoviscosity...Continue Reading

References

Jan 1, 1997·British Journal of Haematology·G D LoweF G Fowkes
Jul 9, 2002·British Journal of Clinical Pharmacology·Gordon D O Lowe
Nov 25, 2003·Seminars in Thrombosis and Hemostasis·Michael W Rampling
Nov 25, 2003·Seminars in Thrombosis and Hemostasis·Mirjana Zarkovic, Hau C Kwaan
Apr 6, 2007·Blood·Harland AustinW Craig Hooper
May 26, 2007·Seminars in Thrombosis and Hemostasis·William Blum, Pierluigi Porcu
Oct 22, 2008·American Journal of Epidemiology·Leonardo J TamarizFrederick L Brancati
Jun 3, 2009·Current Vascular Pharmacology·Roberto CastelliAchille Guariglia

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Citations

Apr 18, 2018·Clinical Hemorheology and Microcirculation·Dong Woo ShinHyun Kyung Kim

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BETA
leukapheresis

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