PMID: 1201158Aug 1, 1975Paper

Whole-body and organ Vo2 changes with enflurane, isoflurane, and halothane

British Journal of Anaesthesia
R A Theye, J D Michenfelder

Abstract

This study was designed to determine the effects of enflurane on canine whole-body and individual organ oxygen consumption (Vo2). Whole-body, myocardial, splanchnic, renal, and skeletal muscle Vo2 were determined at enflurane concentrations equivalent to those used in previous studies with halothane and isoflurane. With increasing enflurane concentrations, whole-body Vo2 decreased progressively. The major component of the decrease was a reduction in myocardial Vo2 resulting from a decrease in myocardial external work as a result of a decrease in cardiac output and arterial pressure. Other organs contributed to a lesser extent to the overall decrease in whole-body Vo2. In each respect the findings with enflurance were not significantly different from those with halothane and isoflurane. These findings did support to the view that anaesthetic agents are not general metabolic depressants and that observed changes in whole-body Vo2 reflect the summated changes in individual organ Vo2 occasioned by an anaesthetic-induced change in organ function and metabolic requirements.

Citations

May 8, 2000·Indian Journal of Pediatrics·R H GunawardanaJ U Weerasinghe
Jan 1, 1977·Acta Anaesthesiologica Scandinavica. Supplementum·E L Maunuksela
Sep 26, 2002·The Proceedings of the Nutrition Society·Eva Selldén
Apr 30, 2016·Journal of Applied Physiology·Niels SecherAsger Granfeldt
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D AzoulayH Bismuth
Jan 16, 2008·Current Opinion in Anaesthesiology·Andrew Ian LevinAndre Coetzee
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·M Andreen
Aug 1, 1982·Acta Anaesthesiologica Scandinavica·T StefánssonH Haljamäe
Sep 5, 1998·Anesthesia and Analgesia·E Selldén, S G Lindahl
Jul 11, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·C Kumba, P Van der Linden

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