Whole-body cryostimulation (cryotherapy) provides benefits for fatigue and functional status in multiple sclerosis patients. A case-control study

Acta Neurologica Scandinavica
E MillerB Dugué

Abstract

To study the effects of whole-body cryostimulation (WBC) on fatigue and functional status in multiple sclerosis (MS) patients with different levels of fatigue. Two groups of 24 MS patients with fatigue were studied. At the beginning of the study, the first group presented a Fatigue Severity Scale (FSS) score between 38 and 42 (low-fatigue (LF) group), and the second group had an FSS score between 48 and 52 (high-fatigue (HF) group). Both groups were matched for age and sex. All patients were exposed to 10.3-min session of WBC (one exposure per day at -110°C or lower). Functional status was assessed before and after the series of WBC exposures using the Rivermead Motor Assessment (RMA), the Multiple Sclerosis Impact Scale (MSIS-29), and the Expanded Disability Status Scale (EDSS). The RMA was estimated in three sections: gross function (RMA1), leg and trunk (RMA2), and arm (RMA3). MSIS-29 consists of two subscales assessing the physical (MSIS-29-PHYS) and psychological (MSIS-29-PSYCH) status. In both groups, the WBC sessions induced a significant improvement in the functional status and in the feeling of fatigue. However, the changes observed in HF patients were significantly greater than those observed in LF patients, especiall...Continue Reading

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Citations

Oct 8, 2016·Journal of Thermal Biology·Romain BouzigonBenoit Dugue
Jun 21, 2018·Journal of Human Kinetics·Romain BouzigonFrederic Grappe
Aug 23, 2018·Acta Neurologica Scandinavica·Sara HaghighiCarl-Gerhard Gottfries
Oct 17, 2017·BMJ Case Reports·Justin CarrardDaniel Genné
Oct 14, 2017·Nature Reviews. Neurology·Iris-Katharina Penner, Friedemann Paul
Aug 21, 2020·European Journal of Applied Physiology·Alex Buoite StellaPaolo Manganotti
Jul 26, 2017·Oxidative Medicine and Cellular Longevity·Bronisława Skrzep-PoloczekDominika Stygar
Dec 15, 2020·Pain and Therapy·Carol GarciaAlaa Abd-Elsayed
Nov 12, 2020·Journal of Clinical Medicine·Ewa Zielińska-NowakElżbieta Miller
Feb 26, 2021·Journal of Thermal Biology·Sławomir KujawskiPaweł Zalewski

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