Whole-Body Diffusion-Weighted Imaging in Chronic Recurrent Multifocal Osteomyelitis in Children

PloS One
Nadine LeclairFranz Wolfgang Hirsch

Abstract

Chronic recurrent multifocal osteomyelitis/ chronic non-bacterial osteomyelitis (CRMO/ CNO) is a rare auto-inflammatory disease and typically manifests in terms of musculoskeletal pain. Because of a high frequency of musculoskeletal disorders in children/ adolescents, it can be quite challenging to distinguish CRMO/ CNO from nonspecific musculoskeletal pain or from malignancies. The purpose of this study was to evaluate the visibility of CRMO lesions in a whole-body diffusion-weighted imaging (WB-DWI) technique and its potential clinical value to better characterize MR-visible lesions. Whole-body imaging at 3T was performed in 16 patients (average: 13 years) with confirmed CRMO. The protocol included 2D Short Tau Inversion Recovery (STIR) imaging in coronal and axial orientation as well as diffusion-weighted imaging in axial orientation. Visibility of lesions in DWI and STIR was evaluated by two readers in consensus. The apparent diffusion coefficient (ADC) was measured for every lesion and corresponding reference locations. A total of 33 lesions (on average 2 per patient) visible in STIR and DWI images (b = 800 s/mm2 and ADC maps) were included, predominantly located in the long bones. With a mean value of 1283 mm2/s in lesion...Continue Reading

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Citations

Jul 12, 2017·Pediatric Rheumatology Online Journal·Yurika AtaTomoyuki Saito
May 30, 2019·Hand : Official Journal of the American Association for Hand Surgery·Yasiru G KarunaratneDavid Graham
Jul 11, 2020·Rheumatology·Savvas AndronikouAthimalaipet V Ramanan
Nov 21, 2018·Calcified Tissue International·Kristian BuchPeter Schwarz
Feb 18, 2020·Pediatric Radiology·María NavallasOscar M Navarro
Aug 6, 2018·Pediatric Radiology·Mary-Louise C Greer
Jun 27, 2020·Pediatric Radiology·Pia ZadigLil-Sofie Ording Müller
Jul 3, 2021·Children·Aikaterini KoryllouRaffaella Carlomagno
Aug 16, 2021·Pediatric Rheumatology Online Journal·Martina CapponiAntonella Insalaco
Feb 11, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Teresa GianiRolando Cimaz

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BETA
biopsy

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syngo

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