Whole body metabolic tumor volume is a prognostic marker in patients with newly diagnosed stage 3B non-small cell lung cancer, confirmed with external validation

European Journal of Hybrid Imaging
Brittany Z DashevskyYonglin Pu

Abstract

TNM Stage 3B encompasses a wide range of primary tumor and nodal metastatic tumor burden. This study aimed to evaluate the prognostic value of quantitative FDG PET/CT parameters in patients with newly diagnosed Stage 3B Non-Small Cell Lung Cancer (NSCLC). Institutional review board approved retrospective study identified patients diagnosed with Stage 3B NSCLC (8th edition TNM classification) on baseline FDG PET/CT at two medical centers (Medical centers A and B), between Feb 2004 and Dec 2014. Patients were excluded if they had prior NSCLC treatment or recent diagnosis of a second primary cancer. Quantitative FDG PET/CT parameters including whole body metabolic tumor volume (MTVwb), total lesion glycolysis (TLGwb), and maximum standardized uptake value (SUVmaxwb) were measured from baseline PET/CT using Edge method with Mimvista software. The primary endpoint was overall survival (OS). Cox proportional hazard regression and Kaplan-Meier overall survival analyses were used to test for an association between OS and quantitative FDG PET/CT parameters. The distributions of MTVwb, TLGwb, SUVmaxwb were skewed, so a natural logarithm transformation was applied and the transformed variables [(ln(MTVwb), ln(TLGwb), and ln(SUVmaxwb)] wer...Continue Reading

References

Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Percy LeeBilly W Loo
Sep 29, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Shengri LiaoYonglin Pu
May 31, 2012·International Journal of Computer Assisted Radiology and Surgery·Hao ZhangYonglin Pu
Sep 27, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jonathan A AbelsonBilly W Loo
Aug 21, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Seung Hyup HyunJoon Young Choi
Nov 7, 2013·Journal of Cancer Research and Clinical Oncology·Hyun Woo ChungYoung So
Jan 25, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Melinda C AldrichWilliam J Blot
Aug 8, 2014·The Cancer Journal·Stacey L TannenbaumMargaret M Byrne
Sep 7, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Hyung-Jun ImDong Soo Lee
Feb 18, 2015·Journal of the National Cancer Institute·Nitin OhriMaria Werner-Wasik
Jul 3, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ramón Rami-PortaUNKNOWN IASLC Staging and Prognostic Factors Committee, Advisory Boards and Participating Institutions
Dec 29, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hisao AsamuraUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee, Advisory Board Members, and
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 15, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Particip
Mar 15, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anne Winther-LarsenPeter Meldgaard
Jul 19, 2016·The International Journal of Biochemistry & Cell Biology·Gaetano RoccoAlfredo Budillon
Jul 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckUNKNOWN IASLC Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions

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Citations

Jun 9, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Yonglin PuBill C Penney

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Software Mentioned

Stata
MIMvista

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