Whole Body MRI in the Staging of Esophageal Cancer--A Prospective Comparison with Whole Body 18F-FDG PET-CT

Digestive Surgery
Vinod MalikJames F M Meaney

Abstract

Positron emission tomography and computed tomography (PET-CT) is established in the staging of esophageal cancer. In this study, an MRI protocol was designed to emulate the anatomical (T1-weighed (T1W) and T2W imaging) and functional information (diffusion-weighted imaging) provided by PET-CT. In all, 49 patients with carcinoma of the esophagus underwent PET-CT and whole-body MRI (WBMRI). WBMRI was carried out using dedicated sequences tailored to detect metastatic disease at each area corresponding to the anatomical coverage of PET-CT. Nodal status was determined from histopathology and endoscopic ultrasound biopsy (EUS). PET-CT and WBMRI identified the primary tumor in 46/49 (94%) and 48/49 (98%) patients, respectively. Nodal analysis in patients undergoing surgery (n = 18) yielded sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 27, 100, 100, 47 and 56% for PET-CT, compared with 30, 100, 100, 53 and 61% for WBMRI. When nodal analysis included both surgical specimens and EUS criteria (n = 39), sensitivity, specificity, PPV, NPV and accuracy were 46, 91, 93, 40 and 59% for PET-CT compared with 59, 92, 94, 50 and 67% for WBMRI. Both imaging modalities identified distant ...Continue Reading

Citations

Jan 5, 2019·Asia-Pacific Journal of Clinical Oncology·Ying ZhuJinming Yu
Jan 4, 2019·Combinatorial Chemistry & High Throughput Screening·Hong HuDa Li
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Shaocheng ZhuBin Song
Aug 23, 2016·World Journal of Gastroenterology : WJG·Lin-Na LuoJian-Jun Li
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Sophie E VollenbrockAnnemarieke Bartels-Rutten
Apr 1, 2021·Radiology·Sangjune Laurence LeeMichael F Bassetti
May 29, 2021·The Surgical Clinics of North America·Charles T BakhosAbbas E Abbas

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