PMID: 9430611Jan 31, 1998Paper

Whole-body, peripheral and intestinal endogenous acetate turnover in dogs using stable isotopes

The Journal of Nutrition
E PouteauM Krempf

Abstract

Acetate metabolism supplies about 10% of energy requirements in food-deprived nonruminant animals. This study used a stable isotope dilution method to investigate the fate of acetate in 24-h food-deprived dogs free of colonic fermentation. Three dogs received intravenous bolus injections of 40 or 70 micromol/kg of [1-13C] acetate, and carotid blood was then sampled during a 15-min period to estimate the acetate distribution volume. Ten dogs received intravenous [1-13C] acetate infusions of 1.05 +/- 0.02 or 2.10 +/- 0. 10 micromol/(kg.min) for 120 or 200 min after a prime of 200 or 70 micromol/kg, respectively. Cephalic venous and carotid arterial blood were sampled for all dogs, and portal blood for five. Acetate distribution volume was 0.27 +/- 0.16 L/kg (mean +/- SEM). The concentrations of acetate in arterial (144 +/- 17 micromol/L), venous (155 +/- 20 micromol/L) and portal plasma (131 +/- 16 micromol/L) were not significantly different during infusion, whereas isotopic enrichments [mole percent excess (MPE): labeled acetate/all acetate molecules] in portal (1.2 +/- 0.2 MPE) and venous plasma (1.7 +/- 0.3 and 2.6 +/- 0.7 MPE) were lower than in arterial plasma for both infusion rates (4.9 +/- 0.6 and 7.6 +/- 0.8 MPE, respec...Continue Reading

References

Sep 1, 1979·The Journal of Clinical Investigation·C L SkutchesG A Reichard
Apr 1, 1990·The American Journal of Clinical Nutrition·M J KorudaR G Settle
Aug 1, 1974·The Biochemical Journal·S E KnowlesF J Ballard
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Jul 1, 1994·Biological Mass Spectrometry·C SimoneauM Krempf
Dec 1, 1993·The American Journal of Clinical Nutrition·B BleibergJ M Miles

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Citations

Sep 1, 2007·The British Journal of Nutrition·Etienne PouteauOlivier Ballèvre
Dec 1, 2005·The Journal of Nutrition·E PouteauP Nguyen
Jul 4, 2002·The Journal of Physiology·G van HallG Rådegran
Oct 21, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Michel Beylot
Dec 22, 1999·The American Journal of Physiology·M A PuchowiczH Brunengraber
Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Julia B EwaschukDion R Brocks

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