Whole-body PET with FDG for the diagnosis of recurrent gastric cancer

European Journal of Nuclear Medicine and Molecular Imaging
T De PotterL Mortelmans

Abstract

This retrospective study was designed to assess the accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in diagnosing recurrence of gastric cancer. Thirty-three patients who had received surgical treatment for gastric cancer with curative intent and who had subsequently undergone FDG-PET for suspected recurrence were retrieved from the PET database. All patients were reviewed with full knowledge of prior conventional diagnostic work-up. Results were compared with a gold standard, consisting of histological confirmation or radiological and clinical follow-up. The gold standard established disease recurrence in 20/33 patients (prevalence 61%). Sensitivity and specificity of FDG-PET for the diagnosis of recurrence were 70% (14/20) and 69% (9/13), respectively. Positive and negative predictive values were 78% (14/18) and 60% (9/15), respectively. Of the six false-negative cases, all had intra-abdominal lesions (three had generalised abdominal metastases, one liver metastasis, one local recurrence and one ovarian metastasis). In the subgroup with previous signet cell differentiation of the primary tumour ( n=13, disease prevalence 62%), sensitivity was 62% (5/8) and specificity, 60% (3/5). Survival anal...Continue Reading

Citations

Sep 14, 2004·Annals of Nuclear Medicine·Naoto WatanabeHikaru Seto
Feb 20, 2004·Annals of Nuclear Medicine·Hirofumi KogaHiroshi Honda
Aug 7, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F LordickJ R Siewert
Oct 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Seok-Ki KimJae-Moon Bae
Jun 8, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jeong Won LeeHyeong Cheol Shin
Dec 8, 2005·Abdominal Imaging·S J RosenbaumH Kühl
Jun 11, 2008·Abdominal Imaging·Min Jung ParkByung-Tae Kim
Mar 2, 2006·European Radiology·Jin-Young ChoiKi Whang Kim
Feb 19, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaKoji Murakami
Jun 14, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hyun Woo ChungYoung So
Jun 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemJ Zalcberg
Mar 3, 2009·BMC Cancer·Sung Hoon SimYung-Jue Bang
Dec 16, 2011·World Journal of Gastroenterology : WJG·Elizabeth C Smyth, Manish A Shah
May 2, 2014·World Journal of Gastroenterology : WJG·Chen-Xi Wu, Zhao-Hui Zhu
Jan 19, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Joon Seok LimKi Whang Kim
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Jeonghun KimMyung-Hee Sohn
Oct 24, 2007·La Presse médicale·Jean-Noël TalbotJean-Didier Grange
Jun 9, 2015·PET Clinics·Maarten L DonswijkMarnix G E H Lam
Sep 24, 2015·The Indian Journal of Surgery·Neeraj ChaudharySamiran Nundy
Mar 1, 2011·Nuclear Medicine and Molecular Imaging·Bong-Hoi ChoiJoon-Kee Yoon
Jan 31, 2016·Abdominal Radiology·Tomasz StaniukWojciech Zegarski
Mar 25, 2009·Gastroentérologie Clinique Et Biologique·T Ducloux
Jan 17, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A E DassenK Bosscha
Apr 1, 2008·PET Clinics·Jeremy J ErasmusRoland Hustinx
Aug 5, 2008·Gastrointestinal Endoscopy Clinics of North America·Tsuneo SagaKyosan Yoshikawa
Jun 15, 2007·Surgical Oncology Clinics of North America·Eric H Jensen, Todd M Tuttle
Oct 31, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K OttJ-R Siewert
Jan 15, 2009·Journal of Surgical Oncology·Natalie G Coburn
Jun 15, 2011·Journal of Surgical Oncology·Kyung Ho PakSung Hoon Noh
Mar 7, 2006·Seminars in Nuclear Medicine·Fabio P EstevesRaghuveer K Halkar
Sep 27, 2006·Current Problems in Surgery·Clancy J ClarkEugene Lin
Feb 14, 2006·Best Practice & Research. Clinical Gastroenterology·Bennett B Chin, Paul P L Chang
Oct 19, 2004·Radiologic Clinics of North America·Roland Hustinx
Apr 18, 2008·American Journal of Surgery·Kyo-Young SongCho-Hyun Park
Jun 30, 2015·Ultrasound in Medicine & Biology·Hyun LimYoung Soo Park
Jun 24, 2015·PET Clinics·Nouf MalibariRobert Lisbona

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