Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Renate JonkerM P K J Engelen

Abstract

Carbohydrates (CHO) and leucine (LEU) both have insulinotropic properties, and could therefore enhance the protein anabolic capacity of dietary proteins, which are important nutrients in preventing muscle loss in patients with Chronic Obstructive Pulmonary Disease (COPD). LEU is also known to activate protein anabolic signaling pathways independent of insulin. Based on our previous findings in COPD, we hypothesized that whole body protein anabolism is enhanced to a comparable extent by the separate and combined co-ingestion of CHO and LEU with protein. To disentangle the protein anabolic effects of CHO and/or free LEU when co-ingested with a high-quality protein, we studied 10 patients with moderate to very severe COPD and dyspnea (GOLD: II-IV, mMRC dyspnea scale ≥ 2), at risk for muscle loss, and 10 healthy age- and gender-matched controls. On four occasions, in a single-blind randomized crossover design, each subject ingested a drink containing 0.6 g/kg fat-free mass (ffm) hydrolyzed casein protein with, a) no add-ons (protein), b) 0.3 g/kg ffm CHO (protein + CHO), c) 0.095 g/kg ffm leucine (protein + LEU), d) both add-ons (protein + CHO + LEU). Whole body protein breakdown (PB), protein synthesis (PS), and net protein balanc...Continue Reading

Associated Clinical Trials

Citations

Mar 17, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Matthew S BrookPhilip J Atherton
Jun 9, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Barbara S van der MeijMariëlle P K J Engelen
Jul 2, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Mariangela RondanelliAngelo Guido Corsico
Sep 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E DeutzUNKNOWN NOURISH Study Group
Apr 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sarah K KirschnerMariëlle P K J Engelen
Aug 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marina V VianaMette M Berger
Jun 18, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah K KirschnerMariëlle P K J Engelen

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