Whole-body protein metabolism in chronic heart failure: relationship to anabolic and catabolic hormones.

JPEN. Journal of Parenteral and Enteral Nutrition
Michael J Toth, Dwight E Matthews

Abstract

Patients with chronic heart failure frequently experience profound wasting during the course of the disease, a condition termed cardiac cachexia. Although protein is the primary structural and functional component of most tissues, few studies have examined the effect of heart failure on protein metabolism. Moreover, no study has assessed the relationship of protein turnover to hormonal alterations thought to promote cachexia. Thus, our goal was to determine if whole-body protein metabolism is altered in heart failure patients and to assess the relationship of protein kinetics to circulating levels of anabolic and catabolic hormones. We measured whole-body protein metabolism using 13C-leucine, body composition, and circulating anabolic and catabolic hormone levels in 10 patients with chronic heart failure and 11 elderly controls. No differences in leucine rate of appearance, oxidation, or nonoxidative disposal were noted between heart failure patients and controls. However, in a subgroup of patients characterized by increased resting energy expenditure for their metabolic body size (n = 4; > or = 20% above that predicted from fat-free mass), leucine rate of appearance (mean +/- SE; 146 +/- 6 micromol/min), an index of protein br...Continue Reading

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Citations

Jul 3, 2013·Heart Failure Clinics·Tobias D TrippelStephan von Haehling
Jun 12, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M P K J EngelenN E P Deutz
Apr 19, 2011·International Journal of Cardiology·Roberto AquilaniManuela Verri
Dec 14, 2011·European Journal of Heart Failure·Ming LiuCheuk-Man Yu
Dec 15, 2010·American Heart Journal·Shanmugam UthamalingamJames L Januzzi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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