PMID: 11607571Aug 15, 1995Paper

Whole-body protochordate regeneration from totipotent blood cells

Proceedings of the National Academy of Sciences of the United States of America
Baruch RinkevichL Fishelson

Abstract

Cell differentiation, tissue formation, and organogenesis are fundamental patterns during the development of multicellular animals from the dividing cells of fertilized eggs. Hence, the complete morphogenesis of any developing organism of the animal kingdom is based on a complex series of interactions that is always associated with the development of a blastula, a one-layered hollow sphere. Here we document an alternative pathway of differentiation, organogenesis, and morphogenesis occurring in an adult protochordate colonial organism. In this system, any minute fragment of peripheral blood vessel containing a limited number of blood cells isolated from Botrylloides, a colonial sea squirt, has the potential to give rise to a fully functional organism possessing all three embryonic layers. Regeneration probably results from a small number of totipotent stem cells circulating in the blood system. The developmental process starts from disorganized, chaotic masses of blood cells. At first an opaque cell mass is formed. Through intensive cell divisions, a hollow, blastula-like structure results, which may produce a whole organism within a short period of a week. This regenerative power of the protochordates may be compared with some...Continue Reading

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Citations

Mar 31, 1999·Microscopy Research and Technique·K Kawamura, Y M Sugino
Apr 2, 2005·Methods in Cell Science : an Official Journal of the Society for in Vitro Biology·Claudette Rabinowitz, Baruch Rinkevich
Nov 7, 2009·Development, Growth & Differentiation·Kaz Kawamura, Takeshi Sunanaga
May 29, 2010·Development, Growth & Differentiation·Nagamoto KanekoShigeki Fujiwara
May 13, 1999·Immunological Reviews·B G MagorI L Weissman
Sep 6, 2013·Zoological Science·Yoshito Harada
Jun 21, 2014·Integrative and Comparative Biology·Josien C van Wolfswinkel
Jan 20, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Loriano BallarinLucia Manni
Jul 10, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Federico D BrownBillie J Swalla
Jul 1, 2014·Genesis : the Journal of Genetics and Development·William R Jeffery
Nov 24, 2012·Developmental Biology·Robert J LauzonStefano Tiozzo
Apr 12, 2016·Ecology and Evolution·Elizabeth A SheetsRosana M da Rocha
Oct 23, 2008·Cell Stem Cell·Ayelet VoskoboynikIrving L Weissman
Dec 25, 2012·Developmental Cell·Yuval RinkevichBuki Rinkevich
Oct 30, 2007·Developmental Biology·Yuval RinkevichRam Reshef
Dec 30, 2014·Mechanisms of Ageing and Development·Kaz KawamuraTakeshi Sunanaga
Jan 17, 2002·The Journal of Comparative Neurology·Giovanna ZanioloLucia Manni
Apr 23, 2017·Development·Elijah J SpinaWilliam C Smith
Feb 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ayelet VoskoboynikIrving L Weissman
Jun 30, 2019·The Journal of Experimental Biology·Lisa ZondagMegan J Wilson
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Cinzia FerrarioLoriano Ballarin
Mar 20, 2021·The Science of the Total Environment·Amalia RosnerSébastien Cambier
May 30, 2017·Developmental Biology·Yosef HyamsBaruch Rinkevich
May 4, 2021·Frontiers in Cell and Developmental Biology·Tal GordonNoa Shenkar
Dec 7, 2018·Developmental Biology·Susannah H KassmerAnthony W De Tomaso
Mar 24, 2004·The Journal of Experimental Biology·Claudette Rabinowitz, Baruch Rinkevich
Dec 23, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stefano TiozzoPaolo Burighel
Aug 22, 2021·Developmental Biology·Marta K WawrzyniakSimon Blanchoud
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer

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