PMID: 7037161Apr 1, 1982Paper

Whole bone marrow irradiation for the treatment of multiple myeloma

Cancer
M ColemanM Tulloh

Abstract

Nine patients with multiple myeloma were treated with whole bone marrow irradiation. Six had heavily pretreated disease refractory to chemotherapy. Three had stable disease lightly pretreated by chemotherapy. A modification of the "three and two" total nodal radiation technique was employed. Although varying and often severe treatment related cytopenia occurred, infectious complications, clinical bleeding, and nonhematalogic complications were minimal. Five of nine patients showed a decrease in monoclonal protein components, and one showed an increase during treatment. These preliminary results indicate that a reduction of tumor cell burden may occur in patients following whole bone marrow irradiation and that the technique is feasible. Whole bone marrow irradiation combined with chemotherapy represents a new conceptual therapeutic approach for multiple myeloma.

References

Jul 26, 1979·The New England Journal of Medicine·O R McIntyre
Jan 1, 1974·Antibiotics and Chemotherapy·M Coleman, R T Silver
Feb 1, 1974·The British Journal of Radiology·L Z NisceG J D'Angio
Jun 1, 1970·The Journal of Clinical Investigation·S E Salmon, B A Smith

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Citations

Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·O R McIntyreB Zimmer
Jun 1, 1991·Blood Reviews·N P Rowell, J S Tobias
Jan 1, 1985·Medical and Pediatric Oncology·G A GomezE S Henderson

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