Whole-brain atrophy assessed by proportional- versus registration-based pipelines from 3T MRI in multiple sclerosis

Brain and Behavior
Christopher C HemondRohit Bakshi

Abstract

Whole-brain atrophy is a standard outcome measure in multiple sclerosis (MS) clinical trials as assessed by various software tools. The effect of processing method on the validity of such data obtained from high-resolution 3T MRI is not known. We compared two commonly used methods of quantifying whole-brain atrophy. Three-dimensional T1-weighted and FLAIR images were obtained at 3T in MS (n = 61) and normal control (NC, n = 30) groups. Whole-brain atrophy was assessed by two automated pipelines: (a) SPM8 to derive brain parenchymal fraction (BPF, proportional-based method); (b) SIENAX to derive normalized brain parenchymal volume (BPV, registration method). We assessed agreement between BPF and BPV, as well their relationship to Expanded Disability Status Scale (EDSS) score, timed 25-foot walk (T25FW), cognition, and cerebral T2 (FLAIR) lesion volume (T2LV). Brain parenchymal fraction and BPV showed only partial agreement (r = 0.73) in the MS group, and r = 0.28 in NC. Both methods showed atrophy in MS versus NC (BPF p < 0.01, BPV p < 0.05). Within MS group comparisons, BPF (p < 0.05) but not BPV (p > 0.05) correlated with EDSS score. BPV (p = 0.03) but not BPF (p = 0.08) correlated with T25FW. Both metrics correlated with T2LV...Continue Reading

References

Aug 28, 2001·Brain : a Journal of Neurology·M RovarisUNKNOWN European/Canadian Glatiramer Acetate Study Group
Mar 14, 2002·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardDavid H Miller
Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
Jun 29, 2004·NeuroImage·F SégonneB Fischl
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jan 24, 2006·Lancet Neurology·Robert A Bermel, Rohit Bakshi
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Apr 25, 2007·Neurology·D H MillerUNKNOWN AFFIRM Investigators
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mohit NeemaRohit Bakshi
Jun 10, 2008·Human Brain Mapping·Frederick KlauschenArvid Lundervold
Dec 11, 2008·Neuroimaging Clinics of North America·Antonio GiorgioNicola De Stefano
Oct 3, 2009·Journal of the International Neuropsychological Society : JINS·Brett A ParmenterRalph H B Benedict
Nov 6, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·James M StankiewiczRohit Bakshi
Jun 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardClaudia A M Wheeler-Kingshott
Sep 2, 2011·Human Brain Mapping·Marco BattagliniNicola De Stefano
Oct 14, 2011·The New England Journal of Medicine·Paul O'ConnorUNKNOWN TEMSO Trial Group
Mar 16, 2012·The New England Journal of Medicine·Giancarlo ComiUNKNOWN ALLEGRO Study Group
Jan 22, 2014·CNS Drugs·Nicola De StefanoBernd C Kieseier
Jul 6, 2014·Journal of Neurology·Douglas L ArnoldKatherine T Dawson
Dec 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Elisa Dell'OglioMohit Neema
Apr 4, 2015·PloS One·Birk Diedenhofen, Jochen Musch
Jun 30, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Renxin ChuRohit Bakshi
Dec 22, 2015·Communications for Statistical Applications and Methods·Seongho Kim
Jan 23, 2016·AJNR. American Journal of Neuroradiology·T GranbergM Kristoffersen-Wiberg
Mar 8, 2016·Human Brain Mapping·Veronica PopescuHugo Vrenken
May 31, 2016·Multiple Sclerosis and Related Disorders·Nicola De StefanoMaria Pia Sormani
Sep 4, 2016·Neurology·Douglas L ArnoldUNKNOWN CARE-MS I and CARE-MS II Investigators
Dec 18, 2016·Neurology·Maria A RoccaMassimo Filippi
Dec 22, 2016·The New England Journal of Medicine·Stephen L HauserUNKNOWN OPERA I and OPERA II Clinical Investigators
May 26, 2017·NeuroImage. Clinical·Sandra González-VillàXavier Lladó
Jun 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nico PapinuttoUNKNOWN North American Imaging in Multiple Sclerosis Cooperative(NAIMS)
Jun 24, 2017·AJNR. American Journal of Neuroradiology·R T ShinoharaUNKNOWN NAIMS Cooperative
Aug 23, 2017·Neurology. Neuroimmunology and Neuroinflammation·Ernst-Wilhelm RadueLudwig Kappos

❮ Previous
Next ❯

Citations

Jan 30, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rohit BakshiUNKNOWN SUMMIT consortium
Dec 15, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Tomas UherManuela Vaneckova

❮ Previous
Next ❯

Software Mentioned

Lesion
R
OPERA
SIENAX
FREEDOMS
ALLEGRO
TOADS
FSL
SPM
DEFINE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.