Whole-brain connectivity analysis and classification of spinocerebellar ataxia type 7 by functional MRI

Cerebellum & Ataxias
Carlos R Hernandez-CastilloJuan Fernandez-Ruiz

Abstract

Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder characterized by degeneration of the motor and visual systems. Besides neural deterioration, these patients also show functional connectivity changes linked to the degenerated brain areas. However, it is not known if there are functional connectivity changes in regions not necessarily linked to the areas undergoing structural deterioration. Therefore, in this study we have explored the whole-brain functional connectivity of SCA7 patients in order to find the overall abnormal functional pattern of this disease. Twenty-six patients and age-and-gender-matched healthy controls were recruited. Whole-brain functional connectivity analysis was performed in both groups. A classification algorithm was used to find the discriminative power of the abnormal connections by classifying patients and healthy subjects. Nineteen abnormal functional connections involving cerebellar and cerebral regions were selected for the classification stage. Support vector machine classification reached 92.3% accuracy with 95% sensitivity and 89.6% specificity using a 10-fold cross-validation. Most of the selected regions were well known degenerated brain regions including cerebellar and visual cortic...Continue Reading

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Citations

Feb 19, 2016·Journal of the International Neuropsychological Society : JINS·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz
Aug 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna Niewiadomska-Cimicka, Yvon Trottier
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Aug 11, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz
Apr 29, 2015·Brain Imaging and Behavior·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz
Aug 16, 2016·AJNR. American Journal of Neuroradiology·C R Hernandez-CastilloJ Fernandez-Ruiz
Sep 27, 2018·The European Journal of Neuroscience·Amanda ChirinoJuan Fernandez-Ruiz
Aug 12, 2015·PloS One·Carlos R Hernandez-CastilloJuan Fernandez-Ruiz

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Software Mentioned

MATLAB
FSL

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Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

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