Whole-Brain CT Perfusion to Quantify Acute Ischemic Penumbra and Core

Radiology
Longting LinMark W Parsons

Abstract

Purpose To validate the use of perfusion computed tomography (CT) with whole-brain coverage to measure the ischemic penumbra and core and to compare its performance to that of limited-coverage perfusion CT. Materials and Methods Institutional ethics committee approval and informed consent were obtained. Patients (n = 296) who underwent 320-detector CT perfusion within 6 hours of the onset of ischemic stroke were studied. First, the ischemic volume at CT perfusion was compared with the penumbra and core reference values at magnetic resonance (MR) imaging to derive CT perfusion penumbra and core thresholds. Second, the thresholds were tested in a different group of patients to predict the final infarction at diffusion-weighted imaging 24 hours after CT perfusion. Third, the change in ischemic volume delineated by the optimal penumbra and core threshold was determined as the brain coverage was gradually reduced from 160 mm to 20 mm. The Wilcoxon signed-rank test, concordance correlation coefficient (CCC), and analysis of variance were used for the first, second, and third steps, respectively. Results CT perfusion at penumbra and core thresholds resulted in the least volumetric difference from MR imaging reference values with delay...Continue Reading

References

Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F CalamanteA Connelly
Aug 22, 2007·Computer Methods and Programs in Biomedicine·Sara B CrawfordHuiman X Barnhart
Dec 14, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·O Y BangUNKNOWN UCLA Collateral Investigators
Feb 9, 2008·Stroke; a Journal of Cerebral Circulation·Masashi TakasawaJean-Claude Baron
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Mark W Parsons
Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Jean-Marc OlivotGregory W Albers
Oct 31, 2009·Journal of the Neurological Sciences·Gyanendra KumarRajan Jain
Dec 17, 2009·European Radiology·Mark PageJohn M Troupis
Sep 23, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kohsuke KudoAkira Ogawa
Oct 30, 2010·Journal of Magnetic Resonance Imaging : JMRI·Matus StrakaRoland Bammer
Dec 24, 2010·Cerebrovascular Diseases·Andrew BivardMark Parsons
Jul 21, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bruce C V CampbellUNKNOWN EPITHET–DEFUSE Investigators
Jul 29, 2011·Annals of Neurology·Krishna A DaniUNKNOWN Translational Medicine Research Collaboration Multicentre Acute Stroke Imaging Study
Sep 14, 2011·Archives of Neurology·Bruce C V CampbellMark W Parsons
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Nov 15, 2011·Brain : a Journal of Neurology·Andrew BivardMark Parsons
Dec 23, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Henry MaUNKNOWN EXTEND investigators
Mar 23, 2012·The New England Journal of Medicine·Mark ParsonsChristopher Levi
Aug 4, 2012·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Sep 8, 2012·Lancet Neurology·Maarten G LansbergUNKNOWN DEFUSE 2 study investigators
Nov 12, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Bruce C V CampbellUNKNOWN EXTEND-IA investigators

❮ Previous
Next ❯

Citations

Jul 28, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Longting LinMark W Parsons
May 19, 2017·Topics in Magnetic Resonance Imaging : TMRI·Pradeep KrishnanRichard I Aviv
Mar 16, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Bruce Cv Campbell, Mark W Parsons
Mar 16, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Carlos Garcia-EsperonMark Parsons
Dec 6, 2017·Annals of Neurology·Andrew BivardMark Parsons
Nov 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chushuang ChenMark W Parsons
Nov 22, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Fana AlemsegedBruce Cv Campbell
Jan 21, 2017·Stroke; a Journal of Cerebral Circulation·Andrew BivardMark Parsons
Mar 4, 2018·Stroke; a Journal of Cerebral Circulation·Longting LinMark W Parsons
Nov 7, 2019·The Journal of Craniofacial Surgery·Luo YongjunZhou Junlin
Jan 4, 2020·Stroke; a Journal of Cerebral Circulation·Carlos Garcia-EsperonMark W Parsons
Mar 12, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·D ByrneA Rohr
Jan 4, 2017·International Journal of Molecular Sciences·Bàrbara Laviña
Sep 17, 2020·Stroke; a Journal of Cerebral Circulation·Jianhong YangUNKNOWN INSPIRE Study Group†
Oct 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kambiz NaelAchala Vagal
Jun 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carlos LaredoÁngel Chamorro
Jan 11, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun Woo Goo
Oct 13, 2020·Stroke; a Journal of Cerebral Circulation·Gianluca BrugnaraPhilipp Vollmuth
Dec 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard CamaraJohn H Zhang
Jan 19, 2021·Revue neurologique·C Garcia-EsperonJ M Olivot
Feb 19, 2021·Reviews in the Neurosciences·Guangchen HeYueqi Zhu
Apr 6, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Charlotte M ErmineJean-Claude Baron
Apr 29, 2021·Physics in Medicine and Biology·Sui LiJianhua Ma
Aug 18, 2021·The American Journal of Nursing·Nneka Lotea IfejikaKimberly R Glaser
Aug 24, 2021·Clinical Hemorheology and Microcirculation·Cornelius KruschePhilipp Wiggermann
Aug 24, 2021·Medical Image Analysis·Ezequiel de la RosaDavid Robben
Sep 28, 2021·Stroke; a Journal of Cerebral Circulation·Manal Nicolas-Jilwan, Max Wintermark
Sep 30, 2021·Stroke; a Journal of Cerebral Circulation·Longting LinUNKNOWN INSPIRE Study Group‡
Oct 12, 2021·Journal of Neuroradiology. Journal De Neuroradiologie·Pablo AbbonaSabee Molloi
Nov 18, 2021·CNS Neuroscience & Therapeutics·Andrew BivardUNKNOWN EXTEND investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.