Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse.

Neuroscience Bulletin
Jia-Yu FuXiao-Ming Li

Abstract

The amygdala, which is involved in various behaviors and emotions, is reported to connect with the whole brain. However, the long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus to generate a whole-brain map of inputs to the main cell types in the mouse amygdala. We identified 37 individual regions that projected to neurons expressing vesicular glutamate transporter 2, 78 regions to parvalbumin-expressing neurons, 104 regions to neurons expressing protein kinase C-δ, and 89 regions to somatostatin-expressing neurons. The amygdala received massive projections from the isocortex and striatum. Several nuclei, such as the caudate-putamen and the CA1 field of the hippocampus, exhibited input preferences to different cell types in the amygdala. Notably, we identified several novel input areas, including the substantia innominata and zona incerta. These findings provide anatomical evidence to help understand the precise connections and diverse functions of the amygdala.

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Citations

Jul 16, 2021·The Journal of Clinical Investigation·Yi-Hua ChenTian-Ming Gao
Aug 18, 2021·Molecular Psychiatry·Limeng HuangJ Julius Zhu

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Methods Mentioned

BETA
fluorescence imaging
transgenic

Software Mentioned

ImageJ
GraphPad Prism
GraphPad
Allen Mouse Common Coordinate Framework Reference Atlas
Allen Mouse Common Coordinate Framework

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