Whole brain mapping of water pools and molecular dynamics with rotating frame MR relaxation using gradient modulated low-power adiabatic pulses

NeuroImage
Ovidiu C AndronesiBruce R Rosen

Abstract

Nuclear magnetic resonance (NMR) relaxation in the rotating frame is sensitive to molecular dynamics on the time scale of water molecules interacting with macromolecules or supramolecular complexes, such as proteins, myelin and cell membranes. Hence, longitudinal (T1ρ) and transverse (T2ρ) relaxation in the rotating frame may have a great potential to probe the macromolecular fraction of tissues. This stimulated a large interest in using this MR contrast to image brain under healthy and disease conditions. However, experimental challenges related to the use of intense radiofrequency irradiation have limited the widespread use of T1ρ and T2ρ imaging. Here, we present methodological development to acquire 3D high-resolution or 2D (multi-)slice selective T1ρ and T2ρ maps of the entire human brain within short acquisition times. These improvements are based on a class of gradient modulated adiabatic pulses that reduce the power deposition, provide slice selection, and mitigate artifacts resulting from inhomogeneities of B1 and B0 magnetic fields. Based on an analytical model of the T1ρ and T2ρ relaxation we compute the maps of macromolecular bound water fraction, correlation and exchange time constants as quantitative biomarkers in...Continue Reading

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Citations

Sep 28, 2015·Neuroscience and Biobehavioral Reviews·Carol P WeingartenNan-kuei Chen
Apr 22, 2016·NMR in Biomedicine·Irtiza Ali Gilani, Raimo Sepponen
Jan 10, 2018·Frontiers in Neuroscience·Silvia MangiaShalom Michaeli
Jan 21, 2018·Scientific Reports·Rajiv G MenonRavinder R Regatte
Feb 14, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Casey P JohnsonVincent A Magnotta
Feb 7, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hui DongBen Inglis
Nov 26, 2020·NMR in Biomedicine·Cristina CudalbuVladimír Mlynárik
Dec 22, 2020·Frontiers in Neurology·Ovidiu C AndronesiEva-Maria Ratai
Jan 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yanjie ZhuDong Liang

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