Whole brain radiation alone produces favourable outcomes for AIDS-related primary central nervous system lymphoma in the HAART era

European Journal of Haematology
Hirokazu NagaiSeiji Okada

Abstract

Primary central nervous system lymphoma (PCNSL) related to acquired immunodeficiency syndrome (AIDS) is a lethal disorder, but the recent application of highly active antiretroviral therapy (HAART) has significantly improved prognosis. This retrospective cohort study of AIDS-related PCNSL examined the actual clinical outcomes and prognostic variables affecting overall survival (OS) in the HAART era. Twenty-three newly diagnosed AIDS-related PCNSL at 12 regional centre hospitals for HIV/AIDS in Japan between 2002 and 2008 were consecutively enrolled. The estimated 3-yr OS rate of the entire cohort was 64% (95%CI, 41.0-80.3%). Whole brain radiation therapy (WBRT) had an independent positive impact on survival (WBRT >or=30 Gy vs. others, P = 0.02). Nine of 10 patients with a good performance status (PS) (0-2) remained alive with complete response, whereas 10 (77%) of 13 of those with a poor PS (3-4) died mostly after a short period. The estimated 3-yr OS rate of the groups with a good and poor PS was 100% and 38% (95%CI, 14-63%), respectively (P = 0.01). Leukoencephalopathy (grade >or= 2) developed in 21% of those that survived more than 12 months after radiation. The patients receiving a curative intent radiation dose (>or=30 Gy)...Continue Reading

References

Apr 1, 1988·Brain : a Journal of Neurology·F GrayF Scaravilli
Jun 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M PludaR Yarchoan
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R CrossenE A Neuwelt
Dec 1, 1993·Annals of Internal Medicine·H A Fine, R J Mayer
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Y BlayP Biron
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BowerB G Gazzard
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L E AbreyL M DeAngelis
Mar 17, 2006·Journal of Neurovirology·Antonella CingolaniAndrea Antinori
Apr 28, 2006·Clinical Lymphoma & Myeloma·David M AboulafiaUNKNOWN AIDS Associated Malignancies Clinical Trials Consortium
Aug 3, 2006·Journal of the National Cancer Institute·Mark BowerJustin Stebbing
Oct 9, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C ConillR Vilella
Apr 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Danielle M Doyle, Lawrence H Einhorn

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Citations

Jun 28, 2014·Current Hematologic Malignancy Reports·Elizabeth H PhillipsKate Cwynarski
Mar 31, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·E Gallop-Evans
Jun 14, 2019·Journal of Neuro-oncology·Leon D KaulenJoachim M Baehring
Sep 29, 2011·Current Opinion in Oncology·Alberto González-Aguilar, José Luis Soto-Hernández

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