Whole-brain radiotherapy in the management of brain metastasis

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Deepak KhuntiaMinesh P Mehta

Abstract

Brain metastases are an important cause of morbidity and mortality, afflicting nearly 170,000 Americans annually. The prognosis for these patients is poor, with median survival times measured in months. In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits.

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