Whole-Brain Source-Reconstructed MEG-Data Reveal Reduced Long-Range Synchronization in Chronic Schizophrenia

ENeuro
Jonni HirvonenSatu Palva

Abstract

Current theories of schizophrenia (ScZ) posit that the symptoms and cognitive dysfunctions arise from a dysconnection syndrome. However, studies that have examined this hypothesis with physiological data at realistic time scales are so far scarce. The current study employed a state-of-the-art approach using Magnetoencephalography (MEG) to test alterations in large-scale phase synchronization in a sample of n = 16 chronic ScZ patients, 10 males and n = 19 healthy participants, 10 males, during a perceptual closure task. We identified large-scale networks from source reconstructed MEG data using data-driven analyses of neuronal synchronization. Oscillation amplitudes and interareal phase-synchronization in the 3-120 Hz frequency range were estimated for 400 cortical parcels and correlated with clinical symptoms and neuropsychological scores. ScZ patients were characterized by a reduction in γ-band (30-120 Hz) oscillation amplitudes that was accompanied by a pronounced deficit in large-scale synchronization at γ-band frequencies. Synchronization was reduced within visual regions as well as between visual and frontal cortex and the reduction of synchronization correlated with elevated clinical disorganization. Accordingly, these da...Continue Reading

Citations

May 26, 2018·JAMA Psychiatry·Peter J UhlhaasJoachim Gross
Nov 20, 2020·European Archives of Psychiatry and Clinical Neuroscience·Osama ElyamanyChristoph Mulert
Feb 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Felix HeverAnuradha Sharma
May 4, 2020·Cerebral Cortex Communications·Dominik FrecheNava Levit-Binnun
Sep 25, 2021·Psychiatry and Clinical Neurosciences·Yoji Hirano, Peter J Uhlhaas

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LabVIEW
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MNE

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