Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study

PloS One
Gwang-Won KimGwang-Woo Jeong

Abstract

The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior tempo...Continue Reading

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Citations

Aug 24, 2020·Human Brain Mapping·Franco CaudaTommaso Costa
Jun 5, 2020·Neuroscience Bulletin·Wasana Ediri ArachchiMeng Liang
May 21, 2019·Frontiers in Psychiatry·Kristina NeugebauerThomas Nickl-Jockschat
Jan 27, 2019·International Journal of Impotence Research·Gwang-Won KimGwang-Woo Jeong
Apr 13, 2020·European Archives of Psychiatry and Clinical Neuroscience·YanYan WeiJiJun Wang
Mar 28, 2020·Therapeutic Advances in Chronic Disease·Melanie T AlmonteMaria Francesca Cordeiro
Jun 19, 2021·Human Brain Mapping·Ioannis PappasMark D'Esposito

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Software Mentioned

DARTEI
DARTEL
SPM5
SPSS
SPM8
MRIcron
Statistical Parametric Mapping

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