Whole breast radiotherapy in the lateral decubitus position: a dosimetric and clinical solution to decrease the doses to the organs at risk (OAR)

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Youlia M KirovaA Fourquet

Abstract

To evaluate whole breast 3D-conformal radiotherapy (RT) delivered in the lateral decubitus position (isocentric lateral decubitus [ILD]) and to report the acute toxicity of a series of consecutive patients treated with ILD. From January to December 2010, 56 consecutive patients with large breasts and early-stage breast cancer treated by breast conserving surgery underwent 3D-conformal whole breast RT in the lateral decubitus position. A dose of 50 Gy in 25 fractions via two opposed isocentric beams was prescribed to whole breast, with or without a 16 Gy photon tumor bed boost. Dosimetry of all patients was reviewed, and the acute toxicity of treatment, evaluated weekly using the NCI CTC v3.0 scale, was analyzed. Median age was 57 years (range: 33-71). 85% of patients had a breast circumference of at least 95 cm and 80% had at least a C cup size. Average breast volume was 991 cm(3) (range: 225-2791 cm(3)). Median dose to the breast was 50 Gy, while median dose to the tumor bed was 16 Gy. Grade 1, 2 and 3 dermatitis developed in 37.5%, 58.9% and 1.8% of patients, respectively. From a dosimetric point of view, doses to the ipsilateral lung were extremely low: average V(1Gy), V(2Gy) and V(5Gy) were 26.6%, 9.3% and 0.7%, respectivel...Continue Reading

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Citations

Jan 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mark NiglasJustin Lee
Sep 4, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Louis BazireYoulia M Kirova
Jul 12, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·F LakosiP Coucke
Feb 20, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yoonsun ChungDoo Ho Choi
Aug 25, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y KirovaC Bourgier
Mar 28, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S Ben DhiaY Kirova
Oct 7, 2018·International Journal of Radiation Oncology, Biology, Physics·Fabien MignotFrancois-Clément Bidard
Sep 29, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MsikaY Kirova
May 6, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S KrhiliY M Kirova
Oct 11, 2020·Critical Reviews in Oncology/hematology·Pierre LoapYoulia Kirova
Oct 14, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MsikaY Kirova
Dec 17, 2018·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L BazireY M Kirova
Jun 11, 2021·Current Treatment Options in Oncology·P EllA L Sverdlov
Jul 17, 2021·International Journal of Cancer. Journal International Du Cancer·Pierre LoapYoulia Kirova
Aug 30, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I ChaffaiY Kirova

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