Whole-cell biocatalysis for hydrogen storage and syngas conversion to formate using a thermophilic acetogen

Biotechnology for Biofuels
Fabian M Schwarz, Volker Müller

Abstract

In times of global climate change, the conversion and capturing of inorganic CO2 have gained increased attention because of its great potential as sustainable feedstock in the production of biofuels and biochemicals. CO2 is not only the substrate for the production of value-added chemicals in CO2-based bioprocesses, it can also be directly hydrated to formic acid, a so-called liquid organic hydrogen carrier (LOHC), by chemical and biological catalysts. Recently, a new group of enzymes were discovered in the two acetogenic bacteria Acetobacterium woodii and Thermoanaerobacter kivui which catalyze the direct hydrogenation of CO2 to formic acid with exceptional high rates, the hydrogen-dependent CO2 reductases (HDCRs). Since these enzymes are promising biocatalysts for the capturing of CO2 and the storage of molecular hydrogen in form of formic acid, we designed a whole-cell approach for T. kivui to take advantage of using whole cells from a thermophilic organism as H2/CO2 storage platform. Additionally, T. kivui cells were used as microbial cell factories for the production of formic acid from syngas. This study demonstrates the efficient whole-cell biocatalysis for the conversion of H2 + CO2 to formic acid in the presence of bic...Continue Reading

References

Nov 1, 1975·Analytical Biochemistry·G A KimmichJ S Brand
Apr 1, 1977·FEBS Letters·E Recktenwald, B Hess
Dec 1, 1972·The American Journal of Clinical Nutrition·M P Bryant
Nov 26, 1997·Journal of Bacteriology·S A Braus-StromeyerH L Drake
Sep 2, 2003·Journal of Bacteriology·Amaresh Das, Lars G Ljungdahl
Jan 1, 1932·The Biochemical Journal·M Stephenson, L H Stickland
Apr 3, 2007·Current Opinion in Biotechnology·Anne M HenstraAlfons J M Stams
Jan 26, 2010·Bioresource Technology·Pradeep Chaminda Munasinghe, Samir Kumar Khanal
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael KöpkePeter Dürre
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eva Biegel, Volker Müller
Jan 29, 2011·Journal of the American Chemical Society·Carole BaffertChristophe Léger
Mar 8, 2011·Applied and Environmental Microbiology·Kelly P NevinDerek R Lovley
Dec 20, 2013·Environmental Technology·Frank R BengelsdorfPeter Dürre
Mar 25, 2014·Chemical Reviews·Wolfgang LubitzEdward Reijerse
May 13, 2014·Bioresource Technology·Apostolos AlissandratosChristopher J Easton
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jennifer S McDowallFrank Sargent
Dec 6, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luisa B MaiaIsabel Moura
Jun 21, 2015·Applied and Environmental Microbiology·Johannes Bertsch, Volker Müller
Dec 23, 2015·Biotechnology for Biofuels·Johannes Bertsch, Volker Müller
Feb 7, 2016·Applied and Environmental Microbiology·Marie Charlotte Weghoff, Volker Müller
Jul 28, 2016·Frontiers in Microbiology·Frank R BengelsdorfPeter Dürre
Dec 23, 2016·Accounts of Chemical Research·Patrick PreusterPeter Wasserscheid
Jan 24, 2017·Metabolic Engineering·Fungmin LiewNigel P Minton
Apr 4, 2017·Bioresource Technology·Cláudia MouratoInês A C Pereira
Jun 15, 2017·Microbial Cell Factories·Baixue Lin, Yong Tao
Jan 2, 2018·Current Biology : CB·Magali RogerFrank Sargent
Apr 6, 2018·Biotechnology for Biofuels·Patrick KottenhahnVolker Müller
Sep 7, 2018·Biotechnology for Biofuels·Fabian M SchwarzVolker Müller
Nov 18, 2018·Folia Microbiologica·Lisa-Maria MauerhoferSimon K-M R Rittmann
Mar 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Marie Charlotte Schoelmerich, Volker Müller

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Citations

Jan 12, 2021·Frontiers in Bioengineering and Biotechnology·Alexander Katsyv, Volker Müller
Oct 15, 2021·Extremophiles : Life Under Extreme Conditions·Alexander KatsyvVolker Müller

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