Jun 23, 2010

Whole exome capture in solution with 3 Gbp of data

Genome Biology
Matthew N BainbridgeRichard A Gibbs

Abstract

We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in large scale genomic studies.

Mentioned in this Paper

Exons
Genome
Single Nucleotide Polymorphism Database
Genomics
Sequencing
Sequence Determinations, DNA
Nucleotides
Solutions
Base Pairing
Gene Duplication Abnormality

Related Feeds

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.