Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers

Gastroenterology
Ana I RoblesNickolas Papadopoulos

Abstract

A long duration of inflammatory bowel disease (IBD) increases the risk for colorectal cancer. Mutation analysis of limited numbers of genes has indicated that colorectal tumors that develop in patients with IBD differ from those of patients without IBD. We performed whole-exome sequencing analyses to characterize the genetic landscape of these tumors. We collected colorectal tumor and non-neoplastic tissues from 31 patients with IBD and colorectal cancer (15 with ulcerative colitis, 14 with Crohn's disease, and 2 with indeterminate colitis) and performed whole-exome sequencing analyses of the microdissected tumor and matched nontumor tissues. We identified somatic alterations by comparing matched specimens. The prevalence of mutations in sporadic colorectal tumors was obtained from previously published exome-sequencing studies. Two specimens had somatic mutations in the DNA proofreading or mismatch repair genes POLE, MLH1, and MSH6 and the tumor cells had a hypermutable phenotype. The remaining tumors had, on average, 71 alterations per sample. TP53 was the most commonly mutated gene, with prevalence similar to that of sporadic colorectal tumors (63% of cases). However, tumors from the patients with IBD had a different mutation...Continue Reading

References

Jul 1, 1991·British Journal of Cancer·S M BellP Quirke
Aug 1, 1990·Gastroenterology·G C BurmerP S Rabinovitch
May 1, 1987·Gastroenterology·S J MeltzerM J Cline
Aug 1, 1994·Gastroenterology·S E KernK W Kinzler
Apr 9, 1998·International Journal of Cancer. Journal International Du Cancer·K HolzmannR Porschen
Sep 15, 1998·The Korean Journal of Internal Medicine·H J Kim, S K Chang
Jan 16, 1999·Journal of the National Cancer Institute·S AmbsC C Harris
Feb 14, 2002·Trends in Molecular Medicine·Jonathan M Rhodes, Barry J Campbell
Feb 1, 2002·The New England Journal of Medicine·Giovanni TraversoBert Vogelstein
Mar 5, 2002·Gastroenterology·Florin M SelaruStephen J Meltzer
Mar 15, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Franz FogtJoseph Rueschoff
Aug 16, 2003·Virchows Archiv : an International Journal of Pathology·Shunji MatsumuraWataru Yasui
Nov 10, 2005·Experimental and Molecular Pathology·Daniel W ColliverSusan Galandiuk
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neal K OsbornDavid A Ahlquist
Aug 3, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·William G GlassAlfred M Del Vecchio
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Apr 6, 2007·Gastroenterology·Kazuo KonishiJean-Pierre J Issa
Apr 21, 2007·Acta histochemica·Herman van DekkenC Janneke van der Woude
Oct 13, 2007·Science·Laura D WoodBert Vogelstein
Aug 22, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mashaal DhirNita Ahuja
Dec 3, 2008·The Journal of Biological Chemistry·Lilia TopolYingzi Yang

❮ Previous
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Citations

Mar 1, 2016·Gastroenterology·Sergei I Grivennikov, Fabio Cominelli
Jun 15, 2016·Seminars in Cell & Developmental Biology·Shunsuke KitajimaDavid A Barbie
Aug 16, 2016·The Journal of Clinical Investigation·Daniel Triner, Yatrik M Shah
Sep 15, 2016·Cellular and Molecular Life Sciences : CMLS·Rocío López-PosadasImke Atreya
Dec 20, 2016·Oncogene·I ZandvakiliY Zheng
Feb 9, 2017·Nature Reviews. Gastroenterology & Hepatology·Chang-Ho R ChoiTrevor A Graham
May 11, 2017·The New England Journal of Medicine·Michael S AnglesioIe-Ming Shih
May 20, 2017·British Journal of Cancer·Sanjiban ChakrabartyKapaettu Satyamoorthy
Jun 18, 2017·International Journal of Molecular Sciences·Kazuhiro KobayashiAkira Hara
Mar 27, 2018·Genes, Chromosomes & Cancer·Roger K WolffMartha L Slattery
Apr 1, 2018·The Journal of Pathology·Michaël NoëIe-Ming Shih
Dec 9, 2017·Nature Reviews. Cancer·Kit CurtiusTrevor A Graham
May 18, 2018·Current Opinion in Gastroenterology·William T Clarke, Joseph D Feuerstein
Sep 27, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jaewoo HongP Charles Lin
Feb 11, 2020·Annual Review of Immunology·Shabnam Shalapour, Michael Karin
Jul 12, 2018·Gut·Ann-Marie BakerTrevor A Graham
Jul 19, 2019·The American Journal of Surgical Pathology·Changqing MaReetesh K Pai
Aug 20, 2020·Expert Review of Anticancer Therapy·Alessandro VitelloMarcello Maida
Aug 4, 2020·Molecular Oncology·Chelsea Gerada, Kevin M Ryan
Feb 12, 2017·Gut·Abdul K SirajKhawla S Al-Kuraya
Jun 27, 2018·Inflammatory Bowel Diseases·Meng XueLiangjing Wang
Oct 3, 2018·World Journal of Gastroenterology : WJG·Luca IamartinoMartin Schepelmann
Sep 27, 2018·Journal of Experimental & Clinical Cancer Research : CR·Tingting LiYanqing Ding
Oct 17, 2019·Genes·Monika StastnaVladimir Korinek
Sep 28, 2016·World Journal of Gastroenterology : WJG·Ru ChenSheng Pan
Jan 26, 2017·Frontiers in Immunology·Marie-Hélène Wasmer, Philippe Krebs
Feb 27, 2017·Biotechnology Letters·Soudabeh KavousipourPooneh Mokarram
Nov 6, 2018·Frontiers in Immunology·Ibrahim Al BakirTrevor A Graham
Aug 29, 2019·Nature Reviews. Gastroenterology & Hepatology·NaNa Keum, Edward Giovannucci

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