Whole fungal elicitors boost paclitaxel biosynthesis induction in Corylus avellana cell culture

PloS One
Mina SalehiSiamak Farhadi

Abstract

Paclitaxel is an effective natural-source chemotherapeutic agent commonly applied to treat a vast range of cancers. In vitro Corylus avellana culture has been reported as a promising and inexpensive system for paclitaxel production. Fungal elicitors have been made known as the most efficient strategy for the biosynthesis induction of secondary metabolites in plant in vitro culture. In this research, C. avellana cell suspension culture (CSC) was exposed to cell extract (CE) and culture filtrate (CF) derived from Camarosporomyces flavigenus, either individually or combined treatment, in mid and late log phase. There is no report on the use of whole fungal elicitors (the combined treatment of CE and CF) for the elicitation of secondary metabolite biosynthesis in plant in vitro culture. The combined treatment of CE and CF significantly led to more paclitaxel biosynthesis and secretion than the individual use of them. Also, multivariate statistical approaches including stepwise regression (SR), ordinary least squares regression (OLSR), principal component regression (PCR) and partial least squares regression (PLSR) were used to model and predict paclitaxel biosynthesis and secretion. Based on value account for (VAF), root mean squar...Continue Reading

References

Feb 22, 1979·Nature·P B SchiffS B Horwitz
May 31, 2002·Expert Opinion on Pharmacotherapy·Tarek M Mekhail, Maurie Markman
Apr 26, 2005·Biotechnology Advances·Jian ZhaoRobert Verpoorte
Sep 24, 2005·Nature Immunology·Frederick M Ausubel
Oct 20, 2005·Journal of Bioscience and Bioengineering·Wei Wang, Jian-Jiang Zhong
Oct 20, 2005·Journal of Bioscience and Bioengineering·Jian-Jiang Zhong
Jun 20, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qun ShaoPeter York
Nov 17, 2006·Nature·Jonathan D G Jones, Jeffery L Dangl
Jun 20, 2007·Nature Chemical Biology·Susan C Roberts
Jul 3, 2008·Advances in Biochemical Engineering/biotechnology·Iryna Smetanska
Apr 3, 2012·Trends in Plant Science·Luke G Barrett, Martin Heil
May 31, 2013·Frontiers in Plant Science·Mari-Anne NewmanGitte Erbs
Mar 5, 2014·Drug Design, Development and Therapy·Dongshan ZhangZheng Dong
Nov 19, 2014·Cytotechnology·Mitra JamshidiEbrahim Bemani
Jun 24, 2017·Trends in Microbiology·Ivey GeogheganSarah Gurr
Nov 17, 2017·Scientific Reports·Mina SalehiNaser Safaie
May 2, 2018·Heredity·Caroline DuZhenyu Jia
May 8, 2018·Planta·Claudia A Espinosa-LealSilverio García-Lara
Aug 25, 2018·Scientific Reports·Maryam SalehiSajad Rashidi Monfared
Feb 21, 2019·Journal of Industrial Microbiology & Biotechnology·Mina SalehiSiamak Farhadi

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Citations

Sep 29, 2020·Applied Microbiology and Biotechnology·Mohsen Hesami, Andrew Maxwell Phineas Jones
Feb 1, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mohammad AbbasJeffrey A Stuart

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Methods Mentioned

BETA
PCR
PCA

Software Mentioned

OLSR
XLSTAT
Minitab
GraphPad Prism

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