Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Nature Communications
Coen M AdemaRichard K Wilson

Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

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Datasets Mentioned

BETA
APKA00000000.1
CP013128
SRA480937
SRA480939
SRA480940
SRA480945

Methods Mentioned

BETA
genetic modification
RNAseq

Software Mentioned

GAA
custom
SOAP
WebApollo
Interproscan

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