Whole-genome analysis of Drosophila gastrulation

Current Opinion in Genetics & Development
Angelike Stathopoulos, M Levine

Abstract

Microarray assays and bioinformatics methods have identified many of the genes and associated regulatory DNAs that control the early phases of gastrulation in Drosophila. The localized activities of these genes are coordinated by a nuclear gradient of the maternal regulatory factor, Dorsal, that is established shortly after fertilization. At least half of the Dorsal target genes encode transcription factors or signaling components that lead to the restricted activation of FGF, EGF, and TGF-beta signaling pathways in the mesoderm, neurogenic ectoderm and dorsal ectoderm, respectively. Recent work has yielded insights into how these signaling pathways control gastrulation, particularly in the context of the Dorsal-mediated gene regulation network

References

Dec 22, 1994·Nature·K Staehling-HamptonM Bate
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·J Casal, M Leptin
Jan 1, 1997·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y Yagi, S Hayashi
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Wilson, M Leptin
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Michele MarksteinMichael S Levine
May 25, 2002·Developmental Biology·Angelike Stathopoulos, Michael Levine
Jun 18, 2002·The EMBO Journal·Tatsushi IgakiMasayuki Miura
Aug 30, 2002·Current Opinion in Genetics & Development·Michele Markstein, Michael Levine
Dec 5, 2002·Cell·Angelike StathopoulosMichael Levine
Mar 13, 2003·Development Genes and Evolution·Véronique MorelFrançois Schweisguth
May 16, 2003·Nature·Francesca V Mariani, Gail R Martin
Aug 2, 2003·Oncogene·Saila KauppilaPreet M Chaudhary
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Siegfried Roth
Mar 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Albert Erives, Michael Levine
Apr 13, 2004·Genes & Development·Angelike StathopoulosMichael Levine
May 7, 2004·Development·Michele MarksteinMichael Levine

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Citations

Sep 21, 2005·Nature Methods·Dmitri Papatsenko, Michael Levine
Dec 22, 2005·Nature Reviews. Genetics·Alfonso Martinez Arias, Penelope Hayward
Oct 22, 2008·Molecular BioSystems·Mamta PuriJonathan S Minden
Sep 13, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Russell P WolfeTabassum Ahsan
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joung-Woo HongMichael S Levine
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vivek S ChopraMichael Levine
Aug 5, 2009·Briefings in Functional Genomics & Proteomics·Vivek S Chopra, Mike Levine
Aug 5, 2009·Nucleic Acids Research·Dmitri PapatsenkoMichael Levine
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Gregory T Reeves, Angelike Stathopoulos
Jan 20, 2011·Genes & Development·Jeremy A Lynch, Siegfried Roth
Aug 29, 2006·Genome Biology·Lauren M McIntyreSergey V Nuzhdin
May 16, 2007·PLoS Computational Biology·Robert P Zinzen, Dmitri Papatsenko
Jan 5, 2011·PloS One·Michelangelo von DassowLance A Davidson
Oct 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Frédéric BiemarMichael S Levine
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Frédéric BiemarMichael S Levine
Jul 19, 2012·Annual Review of Cell and Developmental Biology·Lila Solnica-Krezel, Diane S Sepich
Oct 14, 2008·Biochimica Et Biophysica Acta·Anton L Bryantsev, Richard M Cripps
Mar 18, 2008·Seminars in Cell & Developmental Biology·Buzz BaumMargaret P Quinlan
May 28, 2013·Cell·Mounia LaghaMichael S Levine
Aug 19, 2007·Differentiation; Research in Biological Diversity·Christine L ChafferElizabeth D Williams
Mar 3, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Krista C DobiMary K Baylies
Oct 4, 2005·Developmental Cell·Angelike Stathopoulos, Michael Levine
Jan 13, 2009·Developmental Biology·Louisa M Liberman, Angelike Stathopoulos
Jun 6, 2013·Developmental Biology·Thomas BuchtaJeremy A Lynch
Nov 26, 2008·Developmental Biology·Smadar Ben-Tabou de-Leon, Eric H Davidson
May 11, 2005·Developmental Biology·Angelike Stathopoulos, Michael Levine
Sep 26, 2006·Developmental Biology·Timothy BowlerLeslie Pick
May 28, 2016·Trends in Genetics : TIG·Jeremy E Sandler, Angelike Stathopoulos
Feb 24, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian ProthmannRalph A W Rupp
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Samuel H KellerBomyi Lim
Aug 14, 2019·Current Opinion in Genetics & Development·Frank Macabenta, Angelike Stathopoulos
Oct 19, 2007·Development·Michael J Murray, Robert Saint
Jan 18, 2006·Development·Hilary L Ashe, James Briscoe

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