Whole genome analysis of non-optimal codon usage in secretory signal sequences of Streptomyces coelicolor

Bio Systems
Yu-Dong LiHong Zhou

Abstract

Non-optimal (rare) codons have been suggested to reduce translation rate and facilitate secretion in Escherichia coli. In this study, the complete genome analysis of non-optimal codon usage in secretory signal sequences and non-secretory sequences of Streptomyces coelicolor was performed. The result showed that there was a higher proportion of non-optimal codons in secretory signal sequences than in non-secretory sequences. The increased tendency was more obvious when tested with the experimental data of secretory proteins from proteomics analysis. Some non-optimal codons for Arg (AGA, CGU and CGA), Ile (AUA) and Lys (AAA) were significantly over presented in the secretary signal sequences. It may reveal that a balanced non-optimal codon usage was necessary for protein secretion and expression in Streptomyces.

References

Apr 1, 1992·Gene·F Wright, M J Bibb
Oct 5, 1991·Journal of Molecular Biology·J H KinnairdJ R Fincham
Sep 23, 1985·FEBS Letters·D M Burns, I R Beacham
Jan 15, 1997·FEMS Microbiology Letters·R MorosoliD Kluepfel
Aug 1, 1997·Trends in Biotechnology·C BinnieD I Stewart
Mar 6, 1998·Trends in Biotechnology·G Hannig, S C Makrides
Jun 20, 1998·Bioinformatics·J O McInerney
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·P Fekkes, A J Driessen
Aug 28, 2001·Journal of Molecular Evolution·N G Smith, A Eyre-Walker
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Harold TjalsmaJan Maarten van Dijl
Jun 30, 2004·Journal of Molecular Biology·Jannick Dyrløv BendtsenSøren Brunak
Aug 18, 2004·Journal of Biotechnology·Kristien SchaerlaekensLieve Van Mellaert
Sep 1, 2004·Biochemical and Biophysical Research Communications·Peter M PowerMichael P Jennings
Dec 8, 2004·Biotechnology and Bioengineering·Pat S Lee, Kelvin H Lee
Oct 7, 2005·Microbiology·Anders Fuglsang

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Citations

Jan 1, 2008·Bioinformation·Surajit BasakSantasabuj Das
Mar 25, 2009·Trends in Microbiology·Yaramah M ZaluckiMichael P Jennings
Feb 13, 2007·Biochemical and Biophysical Research Communications·Yaramah M Zalucki, Michael P Jennings
May 14, 2011·Biotechnology Journal·Yaramah M ZaluckiMichael P Jennings
Jun 28, 2011·Biochimica Et Biophysica Acta·Yaramah M ZaluckiMichael P Jennings
Mar 17, 2010·Biochimica Et Biophysica Acta·Yaramah M ZaluckiMichael P Jennings
Dec 7, 2007·Biochemical and Biophysical Research Communications·Yaramah M ZaluckiMichael P Jennings
Sep 8, 2012·PLoS Computational Biology·J Christian J Ray, Oleg A Igoshin
Apr 28, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Juan C VilladaWendel Batista da Silveira

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