Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling

BMC Genomics
Chao LiXiaolong Wang

Abstract

Hair follicles (HFs), upon development, undergo repetitive cycles of growth (anagen), regression (catagen), and rest (telogen). The transition between the stages is determined by multiple molecular signals, including DNA methylation, which plays important roles in mammalian cellular identity and is essential for the development of HFs. Secondary hair follicles (SHFs) in cashmere goat exhibit classic cyclic hair development, and little has been done on a genome-wide scale to examine potentially methylated genes involved in the hair cyclic transition. Genome-wide DNA methylation profiles between skin tissues sampled during the anagen and telogen stages in cashmere goats were investigated using whole-genome bisulfite sequencing (WGBS). The methylation status was observed to be higher in the skin samples with HFs in the telogen than those in the anagen stage. A total of 1311 differentially methylated regions (DMRs) were identified between the two groups, which contained 493 fully annotated DMR-related genes (DMGs) (269 Hyper- DMGs and 224 Hypo-DMGs). Furthermore, a significant over-representation of the functional categories for DMGs related to immune response and intercellular crosstalk during hair cycling was observed. By integra...Continue Reading

References

Apr 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·D J HulmesE Kessler
Dec 3, 2003·Nature Cell Biology·Agnieszka KobielakElaine Fuchs
Sep 18, 2004·The Journal of Investigative Dermatology·Ryan F L O'ShaughnessyAngela M Christiano
Jul 3, 2007·Genome Biology·James M Flanagan, Laurence Wild
Feb 13, 2009·Current Biology : CB·Marlon R SchneiderRalf Paus
Jul 25, 2009·PLoS Genetics·Kevin K LinBogi Andersen
Jun 5, 2010·PLoS Genetics·Elke GrönnigerFrank Lyko
Jul 9, 2010·Nature·Alika K MaunakeaJoseph F Costello
Nov 26, 2010·Developmental Cell·Matthew LeBoeufSarah E Millar
Feb 14, 2012·The Journal of Investigative Dermatology·Johann E Gudjonsson, Gerald Krueger
Jul 31, 2012·Molecular Cell·Christoph BockAlexander Meissner
Oct 5, 2012·Genome Biology·Kasper D HansenRafael A Irizarry
Jan 15, 2013·Current Opinion in Genetics & Development·Ruth E Baker, Philip J Murray
Jan 9, 2014·BMC Genomics·Jianmin SuYong Zhang
Jul 17, 2014·BMC Genomics·Ja-Rang LeeHeui-Soo Kim
Jul 22, 2014·Experimental Dermatology·Maksim V PlikusDenise L Gay
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Apr 22, 2016·Nucleic Acids Research·Jüri ReimandJaak Vilo
Jun 25, 2017·BMC Genomics·Stefano FrattiniPaola Crepaldi

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Citations

Apr 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiaomu HuJiajie Zhu
Mar 11, 2020·International Journal of Molecular Sciences·Xiaodong TanJie Wen
Dec 7, 2019·Archives Animal Breeding·Haiyu ZhaoXianyong Lan
Aug 19, 2020·Animals : an Open Access Journal From MDPI·Sen MaYulin Chen
Mar 13, 2021·Frontiers in Genetics·Mengqi Wang, Eveline M Ibeagha-Awemu
Apr 21, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhanwei YangWenjun Wang

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Methods Mentioned

BETA
methylation profiling
WGBS
RNA-seq
PCR

Software Mentioned

EdgeR Bioconductor
Bowtie
EdgeR
Illumina
cBot Cluster Generation System
R
: Profiler
bsseq
HTSeq package

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