Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules

BMC Evolutionary Biology
Unni Grimholt

Abstract

In sharks, chickens, rats, frogs, medaka and zebrafish there is haplotypic variation in MHC class I and closely linked genes involved in antigen processing, peptide translocation and peptide loading. At least in chicken, such MHCIa haplotypes of MHCIa, TAP2 and Tapasin are shown to influence the repertoire of pathogen epitopes being presented to CD8+ T-cells with subsequent effect on cell-mediated immune responses. Examining MHCI haplotype variation in Atlantic salmon using transcriptome and genome resources we found little evidence for polymorphism in antigen processing genes closely linked to the classical MHCIa genes. Looking at other genes involved in MHCI assembly and antigen processing we found retention of functional gene duplicates originating from the second vertebrate genome duplication event providing cyprinids, salmonids, and neoteleosts with the potential of several different peptide-loading complexes. One of these gene duplications has also been retained in the tetrapod lineage with orthologs in frogs, birds and opossum. We postulate that the unique salmonid whole genome duplication (SGD) is responsible for eliminating haplotypic content in the paralog MHCIa regions possibly due to frequent recombination and reorg...Continue Reading

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Citations

Jan 5, 2019·Current Pharmaceutical Design·Thea MagroneEmilio Jirillo
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Apr 8, 2020·Journal of Veterinary Research·Michał StosikWiesław Deptuła
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Jan 31, 2021·BMC Ecology and Evolution·U Grimholt, M Lukacs

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Datasets Mentioned

BETA
GBTD01219587.1
EZ768376.1
GBRB01034973.1
AB162343
SRR1422872

Methods Mentioned

BETA
glycosylation

Software Mentioned

Clustal X
CLC Genomic Workbench
FGENESH
Ensembl
MEGA7
blastN
TblastN

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