Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.

Antimicrobial Agents and Chemotherapy
Michele IaconoAlessandra Carattoli

Abstract

The whole-genome sequence of an epidemic, multidrug-resistant Acinetobacter baumannii strain (strain ACICU) belonging to the European clone II group and carrying the plasmid-mediated bla(OXA)(-)(58) carbapenem resistance gene was determined. The A. baumannii ACICU genome was compared with the genomes of A. baumannii ATCC 17978 and Acinetobacter baylyi ADP1, with the aim of identifying novel genes related to virulence and drug resistance. A. baumannii ACICU has a single chromosome of 3,904,116 bp (which is predicted to contain 3,758 genes) and two plasmids, pACICU1 and pACICU2, of 28,279 and 64,366 bp, respectively. Genome comparison showed 86.4% synteny with A. baumannii ATCC 17978 and 14.8% synteny with A. baylyi ADP1. A conspicuous number of transporters belonging to different superfamilies was predicted for A. baumannii ACICU. The relative number of transporters was much higher in ACICU than in ATCC 17978 and ADP1 (76.2, 57.2, and 62.5 transporters per Mb of genome, respectively). An antibiotic resistance island, AbaR2, was identified in ACICU and had plausibly evolved by reductive evolution from the AbaR1 island previously described in multiresistant strain A. baumannii AYE. Moreover, 36 putative alien islands (pAs) were de...Continue Reading

References

Jul 1, 1968·Journal of Bacteriology·P Baumann
May 1, 1968·Journal of Bacteriology·P BaumannR Y Stanier
Jul 1, 1968·The Journal of Pathology and Bacteriology·F A Brandt, V van Niekerk
Apr 1, 1996·Clinical Microbiology Reviews·E Bergogne-Bérézin, K J Towner
Mar 21, 1998·Nucleic Acids Research·A V Lukashin, M Borodovsky
Nov 11, 1999·Nucleic Acids Research·A L DelcherS L Salzberg
Jul 9, 2003·Briefings in Bioinformatics·Matt Berriman, Kim Rutherford
Jan 20, 2004·Journal of Medical Microbiology·Alexandr NemecTanny J K van der Reijden
Jul 3, 2004·Genome Research·Aaron C E DarlingNicole T Perna
Aug 11, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Van LooverenUNKNOWN ARPAC Steering Group
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Isabelle MarchandThierry Lambert
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jun 28, 2005·Nucleic Acids Research·John Besemer, Mark Borodovsky
Aug 17, 2005·Emerging Infectious Diseases·Kepler A DavisPaula J Gray
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert GaynesUNKNOWN National Nosocomial Infections Surveillance System
Jan 18, 2006·PLoS Genetics·Pierre-Edouard FournierJean-Michel Claverie
Jan 31, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C HéritierP Nordmann
Apr 25, 2006·FEMS Microbiology Letters·Jane F TurtonTyrone L Pitt
Aug 9, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis B Rice
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Alessia BertiniAlessandra Carattoli
Jul 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J F TurtonT L Pitt
Nov 17, 2007·Cellular Microbiology·Young Ran KimJoon Haeng Rhee
Nov 17, 2007·Nature Reviews. Microbiology·Lenie DijkshoornHarald Seifert
Dec 19, 2007·Antimicrobial Agents and Chemotherapy·Laurence Damier-PiollePatrice Courvalin

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Citations

Aug 4, 2011·Microbial Ecology·Asli I Özen, David W Ussery
Feb 4, 2010·The Journal of Microbiology·Ji-Hyun ShinJungmin Kim
Dec 17, 2008·Nature Reviews. Microbiology·Helena Seth-Smith, Alan Walker
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Evan S SnitkinJulie A Segre
Nov 8, 2008·The Journal of Antimicrobial Chemotherapy·Jennifer K MakPeter A White
Nov 22, 2008·The Journal of Antimicrobial Chemotherapy·Farha ShaikhKumar Rajakumar
Apr 9, 2010·The Journal of Antimicrobial Chemotherapy·Virginia PostRuth M Hall
Jun 19, 2010·The Journal of Antimicrobial Chemotherapy·Lenka Krizova, Alexandr Nemec
Jul 27, 2010·The Journal of Antimicrobial Chemotherapy·Gabriela J Da SilvaAida Duarte
Oct 25, 2011·The Journal of Antimicrobial Chemotherapy·Steven J Nigro, Ruth M Hall
Feb 22, 2012·The Journal of Antimicrobial Chemotherapy·Steven J Nigro, Ruth M Hall
Aug 11, 2010·Antimicrobial Agents and Chemotherapy·Sébastien CoyneBruno Périchon
Jun 3, 2009·Antimicrobial Agents and Chemotherapy·Marco Maria D'AndreaGian Maria Rossolini
May 4, 2011·Antimicrobial Agents and Chemotherapy·Lenka KrizovaAlexandr Nemec
Aug 30, 2008·Antimicrobial Agents and Chemotherapy·Raffaele ZarrilliMaria Triassi
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Alessia BertiniAlessandra Carattoli
Jul 7, 2011·Antimicrobial Agents and Chemotherapy·Mar SoléJordi Vila
Sep 23, 2009·Antimicrobial Agents and Chemotherapy·Vijaya Bharathi SrinivasanWondwossen A Gebreyes
Sep 22, 2010·Antimicrobial Agents and Chemotherapy·Jennifer H MoffattJohn D Boyce
Jun 7, 2012·Antimicrobial Agents and Chemotherapy·Dae Hun KimKwan Soo Ko
Dec 24, 2009·Antimicrobial Agents and Chemotherapy·M Indriati HoodEric P Skaar
Nov 4, 2009·Antimicrobial Agents and Chemotherapy·Sébastien CoyneBruno Périchon
Jul 27, 2011·Antimicrobial Agents and Chemotherapy·Hua ZhouYunsong Yu
Dec 22, 2010·Antimicrobial Agents and Chemotherapy·Sébastien CoyneBruno Périchon
Apr 15, 2009·Antimicrobial Agents and Chemotherapy·Virginia Post, Ruth M Hall
Sep 12, 2012·Antimicrobial Agents and Chemotherapy·Luísa C S AntunesPaolo Visca
Dec 7, 2011·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Feb 1, 2012·Antimicrobial Agents and Chemotherapy·Vaida SeputieneEdita Suziedeliene
Mar 15, 2011·Journal of Bacteriology·Chun-Chen ChenShu-Ying Li
Oct 22, 2008·Journal of Bacteriology·Mark D AdamsSteven R Gill
Oct 5, 2010·Journal of Bacteriology·María A MussiLuis A Actis

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