Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle

BMC Genetics
Paula NicoliniFrancisco Peñagaricano

Abstract

Service sire has a considerable impact on reproductive success in dairy cattle. Most gene mapping studies for bull fertility have focused on additive effects, while non-additive effects have been largely ignored. The main goal of this study was to assess the relevance of non-additive effects on Sire Conception Rate (SCR) in Holstein dairy cattle. The analysis included 7.5 k Holstein bulls with both SCR records and 57.8 k single nucleotide polymorphism (SNP) markers spanning the entire genome. The importance of non-additive effects was evaluated using an efficient two-step mixed model-based approach. Four genomic regions located on chromosomes BTA8, BTA9, BTA13 and BTA17 showed marked dominance and/or recessive effects. Most of these regions harbor genes, such as ADAM28, DNAJA1, TBC1D20, SPO11, PIWIL3 and TMEM119, that are directly implicated in testis development, male germ line maintenance, and sperm maturation. This study provides further evidence for the relevance of non-additive effects in fitness-related traits, such as male fertility. In addition, these findings may point out new strategies for improving service sire fertility in dairy cattle via marker-assisted selection.

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Citations

Aug 16, 2018·Animal Genetics·F M RezendeF Peñagaricano
Feb 5, 2019·Journal of Dairy Science·Fernanda M RezendeFrancisco Peñagaricano
Jan 23, 2020·International Journal of Molecular Sciences·Shuwen ShanBertram Brenig
Feb 18, 2020·Journal of Dairy Science·Hendyel A PachecoFrancisco Peñagaricano
Jul 27, 2020·Translational Animal Science·Madison L ButlerMegan M Rolf
Feb 26, 2020·Genetics, Selection, Evolution : GSE·Rostam Abdollahi-ArpanahiFrancisco Peñagaricano
Oct 26, 2020·Molecular Biology Reports·Varinder Singh RainaVikas Vohra
May 25, 2021·Animal Genetics·R Abdollahi-ArpanahiF Peñagaricano
Jul 27, 2021·Journal of Dairy Science·Hendyel A PachecoFrancisco Peñagaricano

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Software Mentioned

R package MixABEL
R package GenABEL

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