Whole genome scan to detect chromosomal regions affecting multiple traits in dairy cattle

Journal of Dairy Science
C SchrootenH Bovenhuis

Abstract

Chromosomal regions affecting multiple traits (multiple trait quantitative trait regions or MQR) in dairy cattle were detected using a method based on results from single trait analyses to detect quantitative trait loci (QTL). The covariance between contrasts for different traits in single trait regression analysis was computed. A chromosomal region was considered an MQR when the observed covariance between contrasts deviated from the expected covariance under the null hypothesis of no pleiotropy or close linkage. The expected covariance and the confidence interval for the expected covariance were determined by permutation of the data. Four categories of traits were analyzed: production (5 traits), udder conformation (6 traits), udder health (2 traits), and fertility (2 traits). The analysis of a granddaughter design involving 833 sons of 20 grandsires resulted in 59 MQR (alpha = 0.01, chromosomewise). Fifteen MQR were found on Bos taurus autosome (BTA) 14. Four or more MQR were found on BTA 6, 13, 19, 22, 23, and 25. Eight MQR involving udder conformation and udder health and 4 MQR involving production traits and udder health were found. Five MQR were identified for combinations of fertility and udder conformation traits, and ...Continue Reading

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Citations

Nov 19, 2013·Genome Génome / Conseil National De Recherches Canada·Duc LuStephen P Miller
Jul 5, 2012·Physiological Genomics·D L HadsellP Williamson
Aug 23, 2008·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S Ben JemaaM Gautier
Mar 27, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M ArnyasiA Jávor
Apr 29, 2009·Animal Genetics·G C B SchopenM H P W Visker
Aug 4, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D KolbehdariS S Moore
May 26, 2010·Parasitology Research·Bhavna GuptaAparup Das
Oct 15, 2011·Journal of Mammary Gland Biology and Neoplasia·Gina M Pighetti, A A Elliott
Jul 6, 2020·Journal of Dairy Science·Asha M Miles, Heather J Huson
May 29, 2007·Theriogenology·R F Veerkamp, B Beerda

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