Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia

Antimicrobial Agents and Chemotherapy
Theodore R PakAli Bashir

Abstract

Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against all published complete genomes. Whole-genome sequencing and complete assembly can conclusively identify resistance mechanisms emerging in S. maltophilia strains during clinical therapy.

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Citations

Aug 2, 2019·The Journal of Antimicrobial Chemotherapy·Paula BlancoJosé Luis Martinez
Nov 4, 2020·Antimicrobial Agents and Chemotherapy·Punyawee DulyayangkulMatthew B Avison
Oct 30, 2020·Molecular Biology and Evolution·Yair E Gatt, Hanah Margalit
May 28, 2021·Clinical Microbiology Reviews·Joanna S Brooke

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