Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.

Human Genomics
Shuhua ShenQi Huang

Abstract

Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research. We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity. Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overrepresented. Our study indicated a new mechanism of longevity, suggesting potential genetic variants for further study.

References

Jan 1, 1991·Annals of the New York Academy of Sciences·A M LagaayW Hijmans
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Oct 29, 2000·Human Immunology·C CarusoC Franceschi
Feb 13, 2003·Experimental Gerontology·Domenico LioCalogero Caruso
Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michelangela BarbieriGiuseppe Paolisso
May 21, 2005·Immunity & Ageing : I & a·Federico LicastroCalogero Caruso
May 19, 2006·Nature Reviews. Genetics·Kaare ChristensenJames W Vaupel
Nov 23, 2006·Mechanisms of Ageing and Development·Claudio FranceschiStefano Salvioli
Aug 12, 2008·Ageing Research Reviews·Hae Young ChungChristiaan Leeuwenburgh
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bradley J WillcoxJ David Curb
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Apr 5, 2013·PLoS Genetics·Bethan E PhillipsPhilip J Atherton
Sep 4, 2013·Trends in Genetics : TIG·Arie BudovskyJoão Pedro de Magalhães
Oct 4, 2013·Aging·Nicole Noren HootenMichele K Evans
Feb 19, 2014·Experimental Gerontology·Nuria GaratacheaAlejandro Lucia
Nov 13, 2014·PloS One·Hinco J GiermanStuart K Kim
Apr 17, 2015·Immunological Reviews·Emily L Goldberg, Vishwa Deep Dixit
Apr 29, 2015·Advances in Experimental Medicine and Biology·Erik B van den AkkerMarian Beekman
Oct 4, 2015·Nature·UNKNOWN 1000 Genomes Project ConsortiumGonçalo R Abecasis
Mar 5, 2016·Applied & Translational Genomics·Diddahally GovindarajuNir Barzilai
Jun 11, 2016·Maturitas·Alejandro Santos-LozanoNuria Garatachea
May 14, 2017·BMC Bioinformatics·Sojeong KaJongsun Jung

❮ Previous
Next ❯

Citations

Mar 11, 2021·Briefings in Functional Genomics·Maarouf BaghdadiJoris Deelen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

BWA
PrintReads
SKAT
RealignerTargetCreator
HLAscan
MutsigDB
SAMtools
BaseRecalibrator
IndelRealigner
Picard

Related Concepts

Related Feeds

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Related Papers

Experimental Gerontology
Efstathios S Gonos
Ageing Research Reviews
Diego Marcos-PérezAnder Matheu
Annals of the New York Academy of Sciences
C FranceschiP Sansoni
Archives of Gerontology and Geriatrics. Supplement
L TafaroV Marigliano
© 2022 Meta ULC. All rights reserved