Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016

Emerging Infectious Diseases
Imen BouzouitaLeila Slim Saidi

Abstract

To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012-2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.

References

Jun 21, 2005·Emerging Infectious Diseases·Helmi MardassiKoussay Dellagi
Nov 20, 2012·The Lancet Infectious Diseases·Timothy M WalkerTim E A Peto
Mar 1, 2013·BMC Infectious Diseases·Josephine M BryantDick van Soolingen
May 3, 2014·Journal of Clinical Microbiology·Thomas A KohlStefan Niemann
Oct 23, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D PapaventsisV Nikolayevskyy

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Methods Mentioned

BETA
genotyping

Software Mentioned

Ridom SeqSphere
TGS TB
cgMLST
Ridom SeqSphere +
PhyResSe

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